SOX-1 antibodies in a patient with Crohn’s disease: a case report
Abstract Background The anti-SOX-1 antibodies have been mainly associated with Lambert-Eaton Myasthenic Syndrome (LETMS) and Small-Cell Lung Cancer (SCLC). In this report, we describe the interesting case of a patient with serum anti-SOX-1 antibodies and Crohn’s Disease (CD) with ensuing neurologica...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-022-02923-8 |
| _version_ | 1811223349080096768 |
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| author | Ennio Polilli Antonella Frattari Jessica Elisabetta Esposito Gilda Angelini Annalisa Di Risio Elena Mazzotta Simona Coladonato Giancarlo Di Iorio Giustino Parruti Pierluigi Tocco |
| author_facet | Ennio Polilli Antonella Frattari Jessica Elisabetta Esposito Gilda Angelini Annalisa Di Risio Elena Mazzotta Simona Coladonato Giancarlo Di Iorio Giustino Parruti Pierluigi Tocco |
| author_sort | Ennio Polilli |
| collection | DOAJ |
| description | Abstract Background The anti-SOX-1 antibodies have been mainly associated with Lambert-Eaton Myasthenic Syndrome (LETMS) and Small-Cell Lung Cancer (SCLC). In this report, we describe the interesting case of a patient with serum anti-SOX-1 antibodies and Crohn’s Disease (CD) with ensuing neurological symptoms. Case presentation A Caucasian 67-year-old female was admitted to the Emergency Department with seizures, vertigo, emesis, nausea, postural instability and recurrent falls, over a period of 10 days. She had been affected by Crohn’s Disease since 1991. A CT scan failed to detect any ischemic or haemorrhagic lesion. A brain MRI revealed signs of leukoencephalopathy. Western blot analysis of her serum revealed a high titre of the onconeural antibody anti-SOX1, consistent with a neurological, cerebellar type, paraneoplastic syndrome. In spite of multiple efforts to unmask a possible underlying malignancy, no neoplastic lesion cropped up during hospitalization. Her clinical conditions progressively deteriorated, up to respiratory failure; a few days later she died, due to ensuing septic shock and Multiple Organ Failure. Conclusions Our experience may usher and reveal a new role of anti-neural antibodies, so far reckoned an early indicator of associated malignancy, suggesting that neurological syndromes associated with such antibodies may complicate also chronic Gastrointestinal (GI) diseases. As of now, testing for anti-neuronal antibodies appeared unnecessary within the diagnostic assessment of gastroenterological disorders, which may lead to overlooking incident neurologic autoimmune diseases. Further exploration of such research hypothesis in clinical grounds appears intriguing. |
| first_indexed | 2024-04-12T08:31:22Z |
| format | Article |
| id | doaj.art-f2ea971e08fc49c0b53d48b9ca6931ae |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-12T08:31:22Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-f2ea971e08fc49c0b53d48b9ca6931ae2022-12-22T03:40:13ZengBMCBMC Neurology1471-23772022-11-012211510.1186/s12883-022-02923-8SOX-1 antibodies in a patient with Crohn’s disease: a case reportEnnio Polilli0Antonella Frattari1Jessica Elisabetta Esposito2Gilda Angelini3Annalisa Di Risio4Elena Mazzotta5Simona Coladonato6Giancarlo Di Iorio7Giustino Parruti8Pierluigi Tocco9Clinical Pathology Unit, Pescara General HospitalIntensive Care Unit, Pescara General HospitalClinical Pathology Unit, Pescara General HospitalClinical Pathology Unit, Pescara General HospitalClinical Pathology Unit, Pescara General HospitalInfectious Diseases Unit, Pescara General HospitalInfectious Diseases Unit, Pescara General HospitalClinical Pathology Unit, Pescara General HospitalInfectious Diseases Unit, Pescara General HospitalNeurology and Stroke Unit, Pescara General HospitalAbstract Background The anti-SOX-1 antibodies have been mainly associated with Lambert-Eaton Myasthenic Syndrome (LETMS) and Small-Cell Lung Cancer (SCLC). In this report, we describe the interesting case of a patient with serum anti-SOX-1 antibodies and Crohn’s Disease (CD) with ensuing neurological symptoms. Case presentation A Caucasian 67-year-old female was admitted to the Emergency Department with seizures, vertigo, emesis, nausea, postural instability and recurrent falls, over a period of 10 days. She had been affected by Crohn’s Disease since 1991. A CT scan failed to detect any ischemic or haemorrhagic lesion. A brain MRI revealed signs of leukoencephalopathy. Western blot analysis of her serum revealed a high titre of the onconeural antibody anti-SOX1, consistent with a neurological, cerebellar type, paraneoplastic syndrome. In spite of multiple efforts to unmask a possible underlying malignancy, no neoplastic lesion cropped up during hospitalization. Her clinical conditions progressively deteriorated, up to respiratory failure; a few days later she died, due to ensuing septic shock and Multiple Organ Failure. Conclusions Our experience may usher and reveal a new role of anti-neural antibodies, so far reckoned an early indicator of associated malignancy, suggesting that neurological syndromes associated with such antibodies may complicate also chronic Gastrointestinal (GI) diseases. As of now, testing for anti-neuronal antibodies appeared unnecessary within the diagnostic assessment of gastroenterological disorders, which may lead to overlooking incident neurologic autoimmune diseases. Further exploration of such research hypothesis in clinical grounds appears intriguing.https://doi.org/10.1186/s12883-022-02923-8Anti-SOX1 antibodiesCrohn’s diseaseParaneoplastic neurological syndromes |
| spellingShingle | Ennio Polilli Antonella Frattari Jessica Elisabetta Esposito Gilda Angelini Annalisa Di Risio Elena Mazzotta Simona Coladonato Giancarlo Di Iorio Giustino Parruti Pierluigi Tocco SOX-1 antibodies in a patient with Crohn’s disease: a case report BMC Neurology Anti-SOX1 antibodies Crohn’s disease Paraneoplastic neurological syndromes |
| title | SOX-1 antibodies in a patient with Crohn’s disease: a case report |
| title_full | SOX-1 antibodies in a patient with Crohn’s disease: a case report |
| title_fullStr | SOX-1 antibodies in a patient with Crohn’s disease: a case report |
| title_full_unstemmed | SOX-1 antibodies in a patient with Crohn’s disease: a case report |
| title_short | SOX-1 antibodies in a patient with Crohn’s disease: a case report |
| title_sort | sox 1 antibodies in a patient with crohn s disease a case report |
| topic | Anti-SOX1 antibodies Crohn’s disease Paraneoplastic neurological syndromes |
| url | https://doi.org/10.1186/s12883-022-02923-8 |
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