3D cell sheet structure augments mesenchymal stem cell cytokine production
Abstract Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like microenvironments. Toward this end, this stud...
Main Authors: | Sophia Bou-Ghannam, Kyungsook Kim, David W. Grainger, Teruo Okano |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-04-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-87571-7 |
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