Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models

Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models

Inner hair cell (IHC) Cav1.3 Ca2+ channels are multifunctional channels mediating Ca2+ influx for exocytosis at ribbon synapses, the generation of Ca2+ action potentials in pre-hearing IHCs and gene expression. IHCs of deaf systemic Cav1.3-deficient (Cav1.3-/-) mice stay immature because they fail t...

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Bibliographic Details
Main Authors: Stephanie Eckrich, Dietmar Hecker, Katharina Sorg, Kerstin Blum, Kerstin Fischer, Stefan Münkner, Gentiana Wenzel, Bernhard Schick, Jutta Engel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
inner hair cell
Ca2+ channel
Cav1.3
BK
conditional knockout
flex switch
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00225/full

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