Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study

Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study

Background and rationale: Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as f...

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Main Authors: Jessica Burggraaff, Yao Liu, Juan C. Prieto, Jorge Simoes, Alexandra de Sitter, Serena Ruggieri, Iman Brouwer, Birgit I. Lissenberg-Witte, Mara A. Rocca, Paola Valsasina, Stefan Ropele, Claudio Gasperini, Antonio Gallo, Deborah Pareto, Jaume Sastre-Garriga, Christian Enzinger, Massimo Filippi, Nicola De Stefano, Olga Ciccarelli, Hanneke E. Hulst, Mike P. Wattjes, Frederik Barkhof, Bernard M.J. Uitdehaag, Hugo Vrenken, Charles R.G. Guttmann
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Multiple Sclerosis
MRI
Cognition
Thalamus
Deep grey matter
Atrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158220303867

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