Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos
The function of seminal plasma involves acting as a transport medium for sperm and as a means of communication between the reproductive tissues of the male and female. It is also a vital factor to prime the reproductive tracts of the female for optimal pregnancy. When the reproductive tract of the f...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222004541 |
| _version_ | 1811257108433207296 |
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| author | Hamid Ahmadi Timea Csabai Eva Gorgey Shima Rashidiani Forough Parhizkar Leili Aghebati-Maleki |
| author_facet | Hamid Ahmadi Timea Csabai Eva Gorgey Shima Rashidiani Forough Parhizkar Leili Aghebati-Maleki |
| author_sort | Hamid Ahmadi |
| collection | DOAJ |
| description | The function of seminal plasma involves acting as a transport medium for sperm and as a means of communication between the reproductive tissues of the male and female. It is also a vital factor to prime the reproductive tracts of the female for optimal pregnancy. When the reproductive tract of the female is exposed to seminal plasma, serious alterations take place, enhancing pathogen and debris clearance observed in the uterus throughout mating. It is also capable of supporting embryo growth, promoting the receptivity of the uterus, and establishing tolerance to the semi-allogenic embryo. Moreover, seminal plasma is capable of regulating the functions of several female reproductive organs and providing an ideal condition for effective embryo implantation and pregnancy. It is believed that the health state of the offspring is affected by exposure to seminal plasma. For the treatment of infertility, assisted reproductive technologies have been extensively employed. The application of seminal plasma as a therapeutic approach to enhance the development of embryo competency and rate of implantation, receptivity of endometrium, and establishment of maternal immune tolerance in cycles of ART appears possible. Herein, current knowledge on the composition of seminal plasma and the physiological roles it possesses on various parts of the female reproductive tract are summarized. Moreover, the role of seminal plasma in the development of embryos, implantation, and the following fetal growth and survival have been reviewed in this article. |
| first_indexed | 2024-04-12T17:52:18Z |
| format | Article |
| id | doaj.art-f2f02353e7744d79b7c776ffd732098d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T17:52:18Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f2f02353e7744d79b7c776ffd732098d2022-12-22T03:22:29ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-07-01151113065Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryosHamid Ahmadi0Timea Csabai1Eva Gorgey2Shima Rashidiani3Forough Parhizkar4Leili Aghebati-Maleki5Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, Pécs, HungaryDepartment of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, Pécs, HungaryDepartment of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, Pécs, HungaryDepartment of Medical Biochemistry, Medical School, Pecs University, Pecs, HungaryStem Cell Research Center, Tabriz University of Medical Science, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author at: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.The function of seminal plasma involves acting as a transport medium for sperm and as a means of communication between the reproductive tissues of the male and female. It is also a vital factor to prime the reproductive tracts of the female for optimal pregnancy. When the reproductive tract of the female is exposed to seminal plasma, serious alterations take place, enhancing pathogen and debris clearance observed in the uterus throughout mating. It is also capable of supporting embryo growth, promoting the receptivity of the uterus, and establishing tolerance to the semi-allogenic embryo. Moreover, seminal plasma is capable of regulating the functions of several female reproductive organs and providing an ideal condition for effective embryo implantation and pregnancy. It is believed that the health state of the offspring is affected by exposure to seminal plasma. For the treatment of infertility, assisted reproductive technologies have been extensively employed. The application of seminal plasma as a therapeutic approach to enhance the development of embryo competency and rate of implantation, receptivity of endometrium, and establishment of maternal immune tolerance in cycles of ART appears possible. Herein, current knowledge on the composition of seminal plasma and the physiological roles it possesses on various parts of the female reproductive tract are summarized. Moreover, the role of seminal plasma in the development of embryos, implantation, and the following fetal growth and survival have been reviewed in this article.http://www.sciencedirect.com/science/article/pii/S0753332222004541Seminal PlasmaFemale reproductive tractImplantationPregnancy |
| spellingShingle | Hamid Ahmadi Timea Csabai Eva Gorgey Shima Rashidiani Forough Parhizkar Leili Aghebati-Maleki Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos Biomedicine & Pharmacotherapy Seminal Plasma Female reproductive tract Implantation Pregnancy |
| title | Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos |
| title_full | Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos |
| title_fullStr | Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos |
| title_full_unstemmed | Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos |
| title_short | Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos |
| title_sort | composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos |
| topic | Seminal Plasma Female reproductive tract Implantation Pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222004541 |
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