Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study
Abstract Background Left ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus that precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index in ambulatory adults with diabetes mellitus...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02718-2 |
| _version_ | 1818545923734634496 |
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| author | Boniface Amanee Elias Lumori Edwin Nuwagira Fardous Charles Abeya Abdirahman Ali Araye Godfrey Masette Charles K. Mondo Samson Okello Conrad Muzoora Anthony Muyingo |
| author_facet | Boniface Amanee Elias Lumori Edwin Nuwagira Fardous Charles Abeya Abdirahman Ali Araye Godfrey Masette Charles K. Mondo Samson Okello Conrad Muzoora Anthony Muyingo |
| author_sort | Boniface Amanee Elias Lumori |
| collection | DOAJ |
| description | Abstract Background Left ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus that precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index in ambulatory adults with diabetes mellitus in rural Uganda. Methods We conducted a cross-sectional study, over 5 months, to enroll 195 ambulatory Ugandan adults living with diabetes mellitus for at least five years at Mbarara Regional Referral Hospital. We collected demographic, and clinical data and measured body mass index (BMI). Echocardiography was performed to determine LVDD by assessing the mitral inflow ventricular filling velocities (E/A and E/è ratios), tricuspid regurgitant jet peak velocity, and left atrium maximum volume index. We used logistic regression to estimate the odds ratio for the association of LVDD with BMI and evaluated the variation of associations by age and hypertension status. Results Of the 195 participants, 141 (72.31%) were female, the mean age was 62 [standard deviation, 11.50] years, and the median duration of diabetes diagnosis was 10 [interquartile range, 7, 15] years. Eighty-six percent (n = 168) had LVDD with the majority (n = 127, 65.1%) of participants in the grade 1 category of LVDD. In the adjusted model, the odds of LVDD for each 1 kg/m2 increase in BMI was 1.11 [95% confidence interval 1.00, 1.25, p = 0.04]. The adjusted odds of LVDD among individuals aged ≥ 50 years with BMI ≥ 25 kg/m2 was 13.82 times the odds of LVDD in individuals aged < 50 years with BMI < 25 kg/m2. Conclusion LVDD is prevalent and positively associated with BMI among ambulatory Ugandan adults living with diabetes mellitus for at least five years. The association was higher for older overweight/obese than younger individuals with normal weight. Future studies should focus on the effect of weight loss on LVDD as a possible target for the prevention of heart failure. |
| first_indexed | 2024-12-12T07:46:20Z |
| format | Article |
| id | doaj.art-f2f0d57fbeba48499e9e4c7222a40ca3 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-12T07:46:20Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f2f0d57fbeba48499e9e4c7222a40ca32022-12-22T00:32:35ZengBMCBMC Cardiovascular Disorders1471-22612022-06-012211710.1186/s12872-022-02718-2Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional studyBoniface Amanee Elias Lumori0Edwin Nuwagira1Fardous Charles Abeya2Abdirahman Ali Araye3Godfrey Masette4Charles K. Mondo5Samson Okello6Conrad Muzoora7Anthony Muyingo8Department of Internal Medicine, Mbarara University of Science and TechnologyDepartment of Internal Medicine, Mbarara University of Science and TechnologyDepartment of Internal Medicine, Mbarara University of Science and TechnologyDepartment of Internal Medicine, Mbarara University of Science and TechnologyDepartment of Microbiology and Immunology, Mbarara University of Science and TechnologyUganda Heart Institute, Makerere University College of Health SciencesDepartment of Internal Medicine, Mbarara University of Science and TechnologyDepartment of Internal Medicine, Mbarara University of Science and TechnologyDepartment of Internal Medicine, Mbarara University of Science and TechnologyAbstract Background Left ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus that precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index in ambulatory adults with diabetes mellitus in rural Uganda. Methods We conducted a cross-sectional study, over 5 months, to enroll 195 ambulatory Ugandan adults living with diabetes mellitus for at least five years at Mbarara Regional Referral Hospital. We collected demographic, and clinical data and measured body mass index (BMI). Echocardiography was performed to determine LVDD by assessing the mitral inflow ventricular filling velocities (E/A and E/è ratios), tricuspid regurgitant jet peak velocity, and left atrium maximum volume index. We used logistic regression to estimate the odds ratio for the association of LVDD with BMI and evaluated the variation of associations by age and hypertension status. Results Of the 195 participants, 141 (72.31%) were female, the mean age was 62 [standard deviation, 11.50] years, and the median duration of diabetes diagnosis was 10 [interquartile range, 7, 15] years. Eighty-six percent (n = 168) had LVDD with the majority (n = 127, 65.1%) of participants in the grade 1 category of LVDD. In the adjusted model, the odds of LVDD for each 1 kg/m2 increase in BMI was 1.11 [95% confidence interval 1.00, 1.25, p = 0.04]. The adjusted odds of LVDD among individuals aged ≥ 50 years with BMI ≥ 25 kg/m2 was 13.82 times the odds of LVDD in individuals aged < 50 years with BMI < 25 kg/m2. Conclusion LVDD is prevalent and positively associated with BMI among ambulatory Ugandan adults living with diabetes mellitus for at least five years. The association was higher for older overweight/obese than younger individuals with normal weight. Future studies should focus on the effect of weight loss on LVDD as a possible target for the prevention of heart failure.https://doi.org/10.1186/s12872-022-02718-2Left ventricular diastolic dysfunctionDiabetes mellitusAmbulatory individualsBody mass indexRural Uganda |
| spellingShingle | Boniface Amanee Elias Lumori Edwin Nuwagira Fardous Charles Abeya Abdirahman Ali Araye Godfrey Masette Charles K. Mondo Samson Okello Conrad Muzoora Anthony Muyingo Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study BMC Cardiovascular Disorders Left ventricular diastolic dysfunction Diabetes mellitus Ambulatory individuals Body mass index Rural Uganda |
| title | Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study |
| title_full | Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study |
| title_fullStr | Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study |
| title_full_unstemmed | Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study |
| title_short | Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study |
| title_sort | association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural uganda a cross sectional study |
| topic | Left ventricular diastolic dysfunction Diabetes mellitus Ambulatory individuals Body mass index Rural Uganda |
| url | https://doi.org/10.1186/s12872-022-02718-2 |
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