A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic miceResearch in context

A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic miceResearch in context

Summary: Background: The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million deaths worldwide. Previous investigations into the pathophysiology of SARS-CoV-2 primarily focused on peripheral blood mononuclear...

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Main Authors: Seunghoon Choi, Jusung Lee, Suhyeon Kim, Youn Woo Lee, Gi-Cheon Kim, Seung-Min Hong, Se-Hee An, Hyuna Noh, Kyung Eun Kim, Dain On, Sang Gyu Lee, Hui Jeong Jang, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Da-Jung Kim, Jong-Hwi Yoon, Sang-Hyuk Seok, Yu Jin Lee, Seo Yeon Kim, Young Been Kim, Ji-Yeon Hwang, Hyo-Jung Lee, Hong Bin Kim, Jun Won Park, Jun-Won Yun, Jeon-Soo Shin, Jun-Young Seo, Ki Taek Nam, Kang-Seuk Choi, Ho-Keun Kwon, Ho-Young Lee, Jong Kyoung Kim, Je Kyung Seong
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:EBioMedicine
Subjects:
SARS-CoV-2 infection
K18-hACE2 TG mice
scRNA-seq
Lung inflammation
TGFβ
SPP1
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300498X

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