Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat
Introduction: Artemisia absinthium L. (AA) is a large, diverse genus of the family Asteraceae. AAhas long been used as customary herbal medicine in world for the treatment of gastric pain, cardiacstimulation, improvement of memory and for the restoration of declined mental function. The aimof presen...
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| Format: | Article |
| Language: | English |
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Shahrekord University of Medical Sciences
2016-01-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://www.herbmedpharmacol.com/PDF/JHP-5-29.pdf |
| _version_ | 1828130373048991744 |
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| author | Mohammadian Ali Moradkhani Shirin Ataei Sara Heidary Shayesteh Tavakol Sedaghat Mahsa Kheiripour Nejat Ranjbar Akram |
| author_facet | Mohammadian Ali Moradkhani Shirin Ataei Sara Heidary Shayesteh Tavakol Sedaghat Mahsa Kheiripour Nejat Ranjbar Akram |
| author_sort | Mohammadian Ali |
| collection | DOAJ |
| description | Introduction: Artemisia absinthium L. (AA) is a large, diverse genus of the family Asteraceae. AAhas long been used as customary herbal medicine in world for the treatment of gastric pain, cardiacstimulation, improvement of memory and for the restoration of declined mental function. The aimof present study was to evaluate the hepatoprotective effects of AA on some factors ref lecting thedevelopment of oxidative toxic stress in plasma.Methods: Twenty male rats were equally divided in to 4 groups (5 rats each). Group I actedas control (received normal salin). Treatment groups were II, III and IV which were givenArtemisia 10, 50 and 100 mg/kg/day respectively only by gavage for 24 hours. After treatment,blood specimens were collected. Liver enzymes such as aspartate aminotransferase (AST) andalanine aminotransferase (ALT) with total antioxidant power (TAP) and total thiol groups (TTG)concentrations were measured.Results: Levels of ALT, AST and TTG were decreased in the group II compared to the control(group I). ALT and AST in 50 mg/kg group was observed compared with control group. Also, TTGincreased in Artemisia 50 mg/kg group compared to control group.Conclusion: Results suggests that alcoholic extract of Artemisia can ameliorate liver toxicity inrats through reducing the serum levels of ALT, AST, and oxidative damage. |
| first_indexed | 2024-04-11T16:32:07Z |
| format | Article |
| id | doaj.art-f2f4805ca09940a395c52d43f2f3e4be |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-11T16:32:07Z |
| publishDate | 2016-01-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-f2f4805ca09940a395c52d43f2f3e4be2022-12-22T04:13:59ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042016-01-01512932JHP_1012_20150917112606Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in ratMohammadian Ali0Moradkhani Shirin1Ataei Sara2Heidary Shayesteh Tavakol3Sedaghat Mahsa4Kheiripour Nejat5Ranjbar Akram6Student Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Pharmacogenosy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Biochemistry, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranIntroduction: Artemisia absinthium L. (AA) is a large, diverse genus of the family Asteraceae. AAhas long been used as customary herbal medicine in world for the treatment of gastric pain, cardiacstimulation, improvement of memory and for the restoration of declined mental function. The aimof present study was to evaluate the hepatoprotective effects of AA on some factors ref lecting thedevelopment of oxidative toxic stress in plasma.Methods: Twenty male rats were equally divided in to 4 groups (5 rats each). Group I actedas control (received normal salin). Treatment groups were II, III and IV which were givenArtemisia 10, 50 and 100 mg/kg/day respectively only by gavage for 24 hours. After treatment,blood specimens were collected. Liver enzymes such as aspartate aminotransferase (AST) andalanine aminotransferase (ALT) with total antioxidant power (TAP) and total thiol groups (TTG)concentrations were measured.Results: Levels of ALT, AST and TTG were decreased in the group II compared to the control(group I). ALT and AST in 50 mg/kg group was observed compared with control group. Also, TTGincreased in Artemisia 50 mg/kg group compared to control group.Conclusion: Results suggests that alcoholic extract of Artemisia can ameliorate liver toxicity inrats through reducing the serum levels of ALT, AST, and oxidative damage.http://www.herbmedpharmacol.com/PDF/JHP-5-29.pdfArtemisiaOxidative toxic stressALTASTRat |
| spellingShingle | Mohammadian Ali Moradkhani Shirin Ataei Sara Heidary Shayesteh Tavakol Sedaghat Mahsa Kheiripour Nejat Ranjbar Akram Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat Journal of HerbMed Pharmacology Artemisia Oxidative toxic stress ALT AST Rat |
| title | Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat |
| title_full | Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat |
| title_fullStr | Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat |
| title_full_unstemmed | Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat |
| title_short | Antioxidative and hepatoprotective effects of Artemisia absinthium L. hydroalcholic extract in rat |
| title_sort | antioxidative and hepatoprotective effects of artemisia absinthium l hydroalcholic extract in rat |
| topic | Artemisia Oxidative toxic stress ALT AST Rat |
| url | http://www.herbmedpharmacol.com/PDF/JHP-5-29.pdf |
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