Synthesis, Characterization and Antimicrobial Evaluation of Some New Schiff, Mannich and Acetylenic Mannich Bases Incorporating a 1,2,4-Triazole Nucleus

Synthesis, Characterization and Antimicrobial Evaluation of Some New Schiff, Mannich and Acetylenic Mannich Bases Incorporating a 1,2,4-Triazole Nucleus

A series of Schiff and Mannich bases derived from 4-amino-5-(3-fluoro-phenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione were synthesized. The alkylation of 4-phenyl-5-(3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione with propargyl bromide afforded the corresponding thiopropargylated derivative...

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Bibliographic Details
Main Author: Mohamed R. Aouad
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
Schiff bases
Mannich bases
acetylenic Mannich bases
1,2,4-triazole
antimicrobial activity
Online Access:http://www.mdpi.com/1420-3049/19/11/18897

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