Drug therapy problems among hospitalized patients with cardiovascular disease
Abstract Background Optimal utilization of cardiovascular drugs is crucial in reducing morbidity and mortality associated with cardiovascular diseases. However, the effectiveness of these drugs can be compromised by drug therapy problems. Hospitalized patients with cardiovascular diseases, particula...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-024-03710-8 |
| _version_ | 1797350170368671744 |
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| author | Yirga Legesse Niriayo Roba Kifle Solomon Weldegebreal Asgedom Kidu Gidey |
| author_facet | Yirga Legesse Niriayo Roba Kifle Solomon Weldegebreal Asgedom Kidu Gidey |
| author_sort | Yirga Legesse Niriayo |
| collection | DOAJ |
| description | Abstract Background Optimal utilization of cardiovascular drugs is crucial in reducing morbidity and mortality associated with cardiovascular diseases. However, the effectiveness of these drugs can be compromised by drug therapy problems. Hospitalized patients with cardiovascular diseases, particularly those with multiple comorbidities, polypharmacy, and advanced age, are more susceptible to experiencing drug therapy problems. However, little is known about drug therapy problems and their contributing factors among patients with cardiovascular disease in our setting. Therefore, our study aimed to investigate drug therapy problems and their contributing factors in patients with cardiovascular diseases. Method A prospective observational study was conducted among hospitalized patients with cardiovascular disease at Ayder Comprehensive Specialized Hospital in the Tigray region of Northern Ethiopia from December 2020 to May 2021. We collected the data through patient interviews and review of patients’ medical records. We employed Cipolle’s method to identify and categorize drug therapy problems and sought consensus from a panel of experts through review. Data analysis was performed using the Statistical Software Package SPSS version 22. Binary logistic regression analysis was performed to determine the contributing factors of drug therapy problems in patients with cardiovascular disease. Statistical significance was set at p < 0.05. Results The study included a total of 222 patients, of whom 117 (52.7%) experienced one or more drug-related problems. We identified 177 drug therapy problems equating to 1.4 ± 0.7 drug therapy problems per patients. The most frequently identified DTP was the need for additional drug therapy (32.4%), followed by ineffective drug therapy (14%), and unnecessary drug therapy (13.1%). The predicting factors for drug therapy problems were old age (AOR: 3.97, 95%CI: 1.68–9.36) and number of medications ≥ 5 (AOR: 2.68, 95%CI: 1.47–5.11). Conclusion More than half of the patients experienced drug therapy problems in our study. Old age and number of medications were the predicting factors of drug therapy problems. Therefore, greater attention and focus should be given to patients who are at risk of developing drug therapy problems. |
| first_indexed | 2024-03-08T12:40:53Z |
| format | Article |
| id | doaj.art-f2f75ff222754460afd8707541562cad |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-08T12:40:53Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f2f75ff222754460afd8707541562cad2024-01-21T12:09:48ZengBMCBMC Cardiovascular Disorders1471-22612024-01-012411910.1186/s12872-024-03710-8Drug therapy problems among hospitalized patients with cardiovascular diseaseYirga Legesse Niriayo0Roba Kifle1Solomon Weldegebreal Asgedom2Kidu Gidey3Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle UniversityDepartment of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle UniversityDepartment of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle UniversityDepartment of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle UniversityAbstract Background Optimal utilization of cardiovascular drugs is crucial in reducing morbidity and mortality associated with cardiovascular diseases. However, the effectiveness of these drugs can be compromised by drug therapy problems. Hospitalized patients with cardiovascular diseases, particularly those with multiple comorbidities, polypharmacy, and advanced age, are more susceptible to experiencing drug therapy problems. However, little is known about drug therapy problems and their contributing factors among patients with cardiovascular disease in our setting. Therefore, our study aimed to investigate drug therapy problems and their contributing factors in patients with cardiovascular diseases. Method A prospective observational study was conducted among hospitalized patients with cardiovascular disease at Ayder Comprehensive Specialized Hospital in the Tigray region of Northern Ethiopia from December 2020 to May 2021. We collected the data through patient interviews and review of patients’ medical records. We employed Cipolle’s method to identify and categorize drug therapy problems and sought consensus from a panel of experts through review. Data analysis was performed using the Statistical Software Package SPSS version 22. Binary logistic regression analysis was performed to determine the contributing factors of drug therapy problems in patients with cardiovascular disease. Statistical significance was set at p < 0.05. Results The study included a total of 222 patients, of whom 117 (52.7%) experienced one or more drug-related problems. We identified 177 drug therapy problems equating to 1.4 ± 0.7 drug therapy problems per patients. The most frequently identified DTP was the need for additional drug therapy (32.4%), followed by ineffective drug therapy (14%), and unnecessary drug therapy (13.1%). The predicting factors for drug therapy problems were old age (AOR: 3.97, 95%CI: 1.68–9.36) and number of medications ≥ 5 (AOR: 2.68, 95%CI: 1.47–5.11). Conclusion More than half of the patients experienced drug therapy problems in our study. Old age and number of medications were the predicting factors of drug therapy problems. Therefore, greater attention and focus should be given to patients who are at risk of developing drug therapy problems.https://doi.org/10.1186/s12872-024-03710-8Cardiovascular diseasesDrug therapy problemsTigray |
| spellingShingle | Yirga Legesse Niriayo Roba Kifle Solomon Weldegebreal Asgedom Kidu Gidey Drug therapy problems among hospitalized patients with cardiovascular disease BMC Cardiovascular Disorders Cardiovascular diseases Drug therapy problems Tigray |
| title | Drug therapy problems among hospitalized patients with cardiovascular disease |
| title_full | Drug therapy problems among hospitalized patients with cardiovascular disease |
| title_fullStr | Drug therapy problems among hospitalized patients with cardiovascular disease |
| title_full_unstemmed | Drug therapy problems among hospitalized patients with cardiovascular disease |
| title_short | Drug therapy problems among hospitalized patients with cardiovascular disease |
| title_sort | drug therapy problems among hospitalized patients with cardiovascular disease |
| topic | Cardiovascular diseases Drug therapy problems Tigray |
| url | https://doi.org/10.1186/s12872-024-03710-8 |
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