Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages

Cholesterol efflux (ChE) from macrophages is an initial step of reverse cholesterol transport (RCT). The ATP-binding cassette transporter A1 (ABCA1) is a key transporter for ChE and its increased expression is regarded to attenuate atherosclerosis. Thus, the identification and characterization of mo...

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Bibliographic Details
Main Authors: Limei Wang, Sarah Wesemann, Liselotte Krenn, Angela Ladurner, Elke H. Heiss, Verena M. Dirsch, Atanas G. Atanasov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
olive oil
erythrodiol
ABCA1
cholesterol efflux
protein degradation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00375/full

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