The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy.
OBJECTIVE:To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS:A total of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5310782?pdf=render |
| _version_ | 1818357055756435456 |
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| author | Zhijuan Chen Yang An Bofeng Zhao Weidong Yang Qing Yu Li Cai Hongyan Ni Jianzhong Yin |
| author_facet | Zhijuan Chen Yang An Bofeng Zhao Weidong Yang Qing Yu Li Cai Hongyan Ni Jianzhong Yin |
| author_sort | Zhijuan Chen |
| collection | DOAJ |
| description | OBJECTIVE:To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS:A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities. ReHo, ALFF, and fALFF were also compared for their diagnostic values. RESULTS:RS-fMRI showed comparable sensitivity to PET (83.3%) and specificity to VEEG (66.7%), respectively, for EZ localization in patients with focal epilepsy. There were no significant differences between RS-fMRI and the other localization techniques in terms of sensitivity, specificity, PPV, and NPV. The sensitivities of ReHo, ALFF, and fALFF were 69.4%, 52.8%, and 38.9%, respectively, and for specificities of 66.7%, 83.3%, and 66.7%, respectively. There were no significant differences among ReHo, ALFF, and fALFF, except that ReHo was more sensitive than fALFF. CONCLUSIONS:RS-fMRI may be an efficient tool for detecting EZs in focal epilepsy patients. |
| first_indexed | 2024-12-13T20:07:02Z |
| format | Article |
| id | doaj.art-f2f8492d635f4ebf9ecfccc0d2e4e9c8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T20:07:02Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f2f8492d635f4ebf9ecfccc0d2e4e9c82022-12-21T23:33:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017209410.1371/journal.pone.0172094The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy.Zhijuan ChenYang AnBofeng ZhaoWeidong YangQing YuLi CaiHongyan NiJianzhong YinOBJECTIVE:To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS:A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities. ReHo, ALFF, and fALFF were also compared for their diagnostic values. RESULTS:RS-fMRI showed comparable sensitivity to PET (83.3%) and specificity to VEEG (66.7%), respectively, for EZ localization in patients with focal epilepsy. There were no significant differences between RS-fMRI and the other localization techniques in terms of sensitivity, specificity, PPV, and NPV. The sensitivities of ReHo, ALFF, and fALFF were 69.4%, 52.8%, and 38.9%, respectively, and for specificities of 66.7%, 83.3%, and 66.7%, respectively. There were no significant differences among ReHo, ALFF, and fALFF, except that ReHo was more sensitive than fALFF. CONCLUSIONS:RS-fMRI may be an efficient tool for detecting EZs in focal epilepsy patients.http://europepmc.org/articles/PMC5310782?pdf=render |
| spellingShingle | Zhijuan Chen Yang An Bofeng Zhao Weidong Yang Qing Yu Li Cai Hongyan Ni Jianzhong Yin The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy. PLoS ONE |
| title | The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy. |
| title_full | The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy. |
| title_fullStr | The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy. |
| title_full_unstemmed | The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy. |
| title_short | The value of resting-state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy. |
| title_sort | value of resting state functional magnetic resonance imaging for detecting epileptogenic zones in patients with focal epilepsy |
| url | http://europepmc.org/articles/PMC5310782?pdf=render |
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