Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for ac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/9/1431 |
| _version_ | 1797481658877739008 |
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| author | Mehdi Shahgolzari Hassan Dianat-Moghadam Afagh Yavari Steven N. Fiering Kathleen Hefferon |
| author_facet | Mehdi Shahgolzari Hassan Dianat-Moghadam Afagh Yavari Steven N. Fiering Kathleen Hefferon |
| author_sort | Mehdi Shahgolzari |
| collection | DOAJ |
| description | Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms. |
| first_indexed | 2024-03-09T22:17:46Z |
| format | Article |
| id | doaj.art-f2fe1050f6fc485bb3bdd5a3491ddd5d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:46Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-f2fe1050f6fc485bb3bdd5a3491ddd5d2023-11-23T19:21:00ZengMDPI AGVaccines2076-393X2022-08-01109143110.3390/vaccines10091431Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer TumorsMehdi Shahgolzari0Hassan Dianat-Moghadam1Afagh Yavari2Steven N. Fiering3Kathleen Hefferon4Dental Research Center, Hamadan University of Medical Sciences, Hamadan 6517838636, IranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 8174673461, IranDepartment of Biology, Payame Noor University, Tehran 193954697, IranDepartment of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, NH 03756, USAVirology Laboratory, Department of Cell & Systems Biology, University of Toronto, Toronto, ON M5S 3B2, CanadaBreast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms.https://www.mdpi.com/2076-393X/10/9/1431plant virusesin situ vaccinationimmunomodulatory agentpassive targetingactive targeting |
| spellingShingle | Mehdi Shahgolzari Hassan Dianat-Moghadam Afagh Yavari Steven N. Fiering Kathleen Hefferon Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors Vaccines plant viruses in situ vaccination immunomodulatory agent passive targeting active targeting |
| title | Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors |
| title_full | Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors |
| title_fullStr | Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors |
| title_full_unstemmed | Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors |
| title_short | Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors |
| title_sort | multifunctional plant virus nanoparticles for targeting breast cancer tumors |
| topic | plant viruses in situ vaccination immunomodulatory agent passive targeting active targeting |
| url | https://www.mdpi.com/2076-393X/10/9/1431 |
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