Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015
Abstract Background Dengue virus serotype 2 (DENV-2) was the major serotype in the 2015 dengue outbreak in Taiwan, while DENV-1 and DENV-3 were dominant between 2005 and 2014. We aimed to investigate whether DENV-2 contributed to disease severity and mortality in the outbreak in Kaohsiung city, Taiw...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01454-3 |
| _version_ | 1797630416875683840 |
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| author | Jih-Jin Tsai Ko Chang Chun-Hong Chen Ching-Len Liao Liang-Jen Chen Yan-Yi Tsai Ching-Yi Tsai Ping-Chang Lin Miao-Chen Hsu Li-Teh Liu |
| author_facet | Jih-Jin Tsai Ko Chang Chun-Hong Chen Ching-Len Liao Liang-Jen Chen Yan-Yi Tsai Ching-Yi Tsai Ping-Chang Lin Miao-Chen Hsu Li-Teh Liu |
| author_sort | Jih-Jin Tsai |
| collection | DOAJ |
| description | Abstract Background Dengue virus serotype 2 (DENV-2) was the major serotype in the 2015 dengue outbreak in Taiwan, while DENV-1 and DENV-3 were dominant between 2005 and 2014. We aimed to investigate whether DENV-2 contributed to disease severity and mortality in the outbreak in Kaohsiung city, Taiwan. Methods We collected serum samples from dengue patients to detect the presence of DENV and determine the serotypes by using quantitative reverse transcription-polymerase chain reaction. Our cohorts comprised 105 DENV-1-infected cases and 1,550 DENV-2-infected cases. Demographic data, DENV serotype, and comorbidities were covariates for univariate and multivariate analyses to explore the association with severity and mortality. Results The results suggested that DENV-1 persisted and circulated, while DENV-2 was dominant during the dengue outbreak that occurred between September and December 2015. However, DENV-2 did not directly contribute to either severity or mortality. Aged patients and patients with diabetes mellitus (DM) or moderate to severe chronic kidney disease (CKD) had a higher risk of developing severe dengue. The mortality of dengue patients was related to a higher Charlson comorbidity index score and severe dengue. Among DENV-2-infected patients and older patients, preexisting anti-dengue IgG, DM, and moderate to severe CKD were associated with severe dengue. Moreover, female sex and severe dengue were associated with a significantly higher risk of death. Conclusions Our findings highlight the importance of timely serological testing in elderly patients to identify potential secondary infections and focus on the meticulous management of elderly patients with DM or moderate to severe CKD to reduce dengue-related death. |
| first_indexed | 2024-03-11T11:07:03Z |
| format | Article |
| id | doaj.art-f2fefa408c9a402e9c715b38b911e834 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-11T11:07:03Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-f2fefa408c9a402e9c715b38b911e8342023-11-12T12:10:48ZengBMCEuropean Journal of Medical Research2047-783X2023-11-0128111510.1186/s40001-023-01454-3Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015Jih-Jin Tsai0Ko Chang1Chun-Hong Chen2Ching-Len Liao3Liang-Jen Chen4Yan-Yi Tsai5Ching-Yi Tsai6Ping-Chang Lin7Miao-Chen Hsu8Li-Teh Liu9Tropical Medicine Center, Kaohsiung Medical University HospitalTropical Medicine Center, Kaohsiung Medical University HospitalNational Mosquito-Borne Diseases Control Research Center, National Health Research InstitutesNational Mosquito-Borne Diseases Control Research Center, National Health Research InstitutesDepartment of Family Medicine, Pingtung Christian HospitalTropical Medicine Center, Kaohsiung Medical University HospitalTropical Medicine Center, Kaohsiung Medical University HospitalTropical Medicine Center, Kaohsiung Medical University HospitalTropical Medicine Center, Kaohsiung Medical University HospitalDepartment of Medical Laboratory Science and Biotechnology, College of Medical Technology, Chung Hwa University of Medical TechnologyAbstract Background Dengue virus serotype 2 (DENV-2) was the major serotype in the 2015 dengue outbreak in Taiwan, while DENV-1 and DENV-3 were dominant between 2005 and 2014. We aimed to investigate whether DENV-2 contributed to disease severity and mortality in the outbreak in Kaohsiung city, Taiwan. Methods We collected serum samples from dengue patients to detect the presence of DENV and determine the serotypes by using quantitative reverse transcription-polymerase chain reaction. Our cohorts comprised 105 DENV-1-infected cases and 1,550 DENV-2-infected cases. Demographic data, DENV serotype, and comorbidities were covariates for univariate and multivariate analyses to explore the association with severity and mortality. Results The results suggested that DENV-1 persisted and circulated, while DENV-2 was dominant during the dengue outbreak that occurred between September and December 2015. However, DENV-2 did not directly contribute to either severity or mortality. Aged patients and patients with diabetes mellitus (DM) or moderate to severe chronic kidney disease (CKD) had a higher risk of developing severe dengue. The mortality of dengue patients was related to a higher Charlson comorbidity index score and severe dengue. Among DENV-2-infected patients and older patients, preexisting anti-dengue IgG, DM, and moderate to severe CKD were associated with severe dengue. Moreover, female sex and severe dengue were associated with a significantly higher risk of death. Conclusions Our findings highlight the importance of timely serological testing in elderly patients to identify potential secondary infections and focus on the meticulous management of elderly patients with DM or moderate to severe CKD to reduce dengue-related death.https://doi.org/10.1186/s40001-023-01454-3DENV-1DENV-2Dengue feverSevere dengueMortalityAnti-dengue IgG |
| spellingShingle | Jih-Jin Tsai Ko Chang Chun-Hong Chen Ching-Len Liao Liang-Jen Chen Yan-Yi Tsai Ching-Yi Tsai Ping-Chang Lin Miao-Chen Hsu Li-Teh Liu Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015 European Journal of Medical Research DENV-1 DENV-2 Dengue fever Severe dengue Mortality Anti-dengue IgG |
| title | Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015 |
| title_full | Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015 |
| title_fullStr | Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015 |
| title_full_unstemmed | Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015 |
| title_short | Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015 |
| title_sort | dengue virus serotype did not contribute to clinical severity or mortality in taiwan s largest dengue outbreak in 2015 |
| topic | DENV-1 DENV-2 Dengue fever Severe dengue Mortality Anti-dengue IgG |
| url | https://doi.org/10.1186/s40001-023-01454-3 |
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