The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise
Alzheimer’s disease (AD) is the leading cause of dementia in the world, accounting for 50–75% of cases. Currently, there is limited treatment for AD. The current pharmacological therapy minimizes symptom progression but does not reverse brain damage. Studies focused on nonpharmacological treatment f...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-08-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2020.00152/full |
| _version_ | 1818610510708342784 |
|---|---|
| author | Leticia R. Dare Alexandre Garcia Caroline B. Soares Luiza Lopes Ben-Hur S. Neves Daniel V. Dias Pâmela B. Mello-Carpes |
| author_facet | Leticia R. Dare Alexandre Garcia Caroline B. Soares Luiza Lopes Ben-Hur S. Neves Daniel V. Dias Pâmela B. Mello-Carpes |
| author_sort | Leticia R. Dare |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the leading cause of dementia in the world, accounting for 50–75% of cases. Currently, there is limited treatment for AD. The current pharmacological therapy minimizes symptom progression but does not reverse brain damage. Studies focused on nonpharmacological treatment for AD have been developed to act on brain plasticity and minimize the neurotoxicity caused by the amyloid-beta (Aβ) peptide. Using a neurotoxicity model induced by Aβ in rats, the present study shows that physical (PE) and cognitive exercise (CE) reverse recognition memory deficits (with a prominent effect of long-term object recognition memory), decrease hippocampal lipid peroxidation, restore the acetylcholinesterase activity altered by Aβ neurotoxicity, and seems to reverse, at least partially, hippocampal tissue disorganization. |
| first_indexed | 2024-12-16T15:15:35Z |
| format | Article |
| id | doaj.art-f300b57f746645ee9c77a7c5a1c0f7e6 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-16T15:15:35Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-f300b57f746645ee9c77a7c5a1c0f7e62022-12-21T22:26:49ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532020-08-011410.3389/fnbeh.2020.00152541195The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive ExerciseLeticia R. Dare0Alexandre Garcia1Caroline B. Soares2Luiza Lopes3Ben-Hur S. Neves4Daniel V. Dias5Pâmela B. Mello-Carpes6Physiology Research Group, Federal University of Pampa, Uruguaiana, BrazilPhysiology Research Group, Federal University of Pampa, Uruguaiana, BrazilPhysiology Research Group, Federal University of Pampa, Uruguaiana, BrazilPhysiology Research Group, Federal University of Pampa, Uruguaiana, BrazilPhysiology Research Group, Federal University of Pampa, Uruguaiana, BrazilDepartment of Structural Biology, Federal University of Triangulo Mineiro, Uberaba, BrazilPhysiology Research Group, Federal University of Pampa, Uruguaiana, BrazilAlzheimer’s disease (AD) is the leading cause of dementia in the world, accounting for 50–75% of cases. Currently, there is limited treatment for AD. The current pharmacological therapy minimizes symptom progression but does not reverse brain damage. Studies focused on nonpharmacological treatment for AD have been developed to act on brain plasticity and minimize the neurotoxicity caused by the amyloid-beta (Aβ) peptide. Using a neurotoxicity model induced by Aβ in rats, the present study shows that physical (PE) and cognitive exercise (CE) reverse recognition memory deficits (with a prominent effect of long-term object recognition memory), decrease hippocampal lipid peroxidation, restore the acetylcholinesterase activity altered by Aβ neurotoxicity, and seems to reverse, at least partially, hippocampal tissue disorganization.https://www.frontiersin.org/article/10.3389/fnbeh.2020.00152/fullAlzheimer’s diseasephysical exercisecognitive exerciseoxidative damageAβ neurotoxicity |
| spellingShingle | Leticia R. Dare Alexandre Garcia Caroline B. Soares Luiza Lopes Ben-Hur S. Neves Daniel V. Dias Pâmela B. Mello-Carpes The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise Frontiers in Behavioral Neuroscience Alzheimer’s disease physical exercise cognitive exercise oxidative damage Aβ neurotoxicity |
| title | The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise |
| title_full | The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise |
| title_fullStr | The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise |
| title_full_unstemmed | The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise |
| title_short | The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise |
| title_sort | reversal of memory deficits in an alzheimer s disease model using physical and cognitive exercise |
| topic | Alzheimer’s disease physical exercise cognitive exercise oxidative damage Aβ neurotoxicity |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2020.00152/full |
| work_keys_str_mv | AT leticiardare thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT alexandregarcia thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT carolinebsoares thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT luizalopes thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT benhursneves thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT danielvdias thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT pamelabmellocarpes thereversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT leticiardare reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT alexandregarcia reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT carolinebsoares reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT luizalopes reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT benhursneves reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT danielvdias reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise AT pamelabmellocarpes reversalofmemorydeficitsinanalzheimersdiseasemodelusingphysicalandcognitiveexercise |