Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules
Abstract The localization of invisible and impalpable small pulmonary nodules has become an important concern during surgery, since current widely used techniques for localization have a number of limitations, such as invasive features of hookwires and microcoils, and rapid diffusion after injection...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-022-01263-6 |
| _version_ | 1828284500299218944 |
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| author | Haoran Ji Xiaofeng Wang Pei Wang Yan Gong Yun Wang Chang Liu Guangyu Ji Xiansong Wang Mingsong Wang |
| author_facet | Haoran Ji Xiaofeng Wang Pei Wang Yan Gong Yun Wang Chang Liu Guangyu Ji Xiansong Wang Mingsong Wang |
| author_sort | Haoran Ji |
| collection | DOAJ |
| description | Abstract The localization of invisible and impalpable small pulmonary nodules has become an important concern during surgery, since current widely used techniques for localization have a number of limitations, such as invasive features of hookwires and microcoils, and rapid diffusion after injection of indocyanine green (ICG). Lanthanide-based metal–organic frameworks (MOFs) have been proven as potential fluorescent agents because of their prominent luminescent characteristics, including large Stokes shifts, high quantum yields, long decay lifetimes, and undisturbed emissive energies. In addition, lanthanides, such as Eu, can efficiently absorb X-rays for CT imaging. In this study, we synthesized Eu-UiO-67-bpy (UiO = University of Oslo, bpy = 2,2'-bipyridyl) as a fluorescent dye with a gelatin-methacryloyl (GelMA) hydrogel as a liquid carrier. The prepared complex exhibits constant fluorescence emission owing to the luminescent characteristics of Eu and the stable structure of UiO-67-bpy with restricted fluorescence diffusion attributed to the photocured GelMA. Furthermore, the hydrogel provides stiffness to make the injection site tactile and improve the accuracy of localization and excision. Finally, our complex enables fluorescence-CT dual-modal imaging of the localization site. |
| first_indexed | 2024-04-13T09:02:48Z |
| format | Article |
| id | doaj.art-f300ca591dc94278a0e5926bb3a9d18c |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T09:02:48Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-f300ca591dc94278a0e5926bb3a9d18c2022-12-22T02:53:05ZengBMCJournal of Nanobiotechnology1477-31552022-02-0120111310.1186/s12951-022-01263-6Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodulesHaoran Ji0Xiaofeng Wang1Pei Wang2Yan Gong3Yun Wang4Chang Liu5Guangyu Ji6Xiansong Wang7Mingsong Wang8Department of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineExcellent Science and Technology Innovation Group of Jiangsu Province, College of Environmental Science, Nanjing Xiaozhuang UniversityDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract The localization of invisible and impalpable small pulmonary nodules has become an important concern during surgery, since current widely used techniques for localization have a number of limitations, such as invasive features of hookwires and microcoils, and rapid diffusion after injection of indocyanine green (ICG). Lanthanide-based metal–organic frameworks (MOFs) have been proven as potential fluorescent agents because of their prominent luminescent characteristics, including large Stokes shifts, high quantum yields, long decay lifetimes, and undisturbed emissive energies. In addition, lanthanides, such as Eu, can efficiently absorb X-rays for CT imaging. In this study, we synthesized Eu-UiO-67-bpy (UiO = University of Oslo, bpy = 2,2'-bipyridyl) as a fluorescent dye with a gelatin-methacryloyl (GelMA) hydrogel as a liquid carrier. The prepared complex exhibits constant fluorescence emission owing to the luminescent characteristics of Eu and the stable structure of UiO-67-bpy with restricted fluorescence diffusion attributed to the photocured GelMA. Furthermore, the hydrogel provides stiffness to make the injection site tactile and improve the accuracy of localization and excision. Finally, our complex enables fluorescence-CT dual-modal imaging of the localization site.https://doi.org/10.1186/s12951-022-01263-6Lanthanide-based metal–organic frameworkGelatin-methacryloylLocalization of small pulmonary nodulesDual-modal imaging |
| spellingShingle | Haoran Ji Xiaofeng Wang Pei Wang Yan Gong Yun Wang Chang Liu Guangyu Ji Xiansong Wang Mingsong Wang Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules Journal of Nanobiotechnology Lanthanide-based metal–organic framework Gelatin-methacryloyl Localization of small pulmonary nodules Dual-modal imaging |
| title | Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules |
| title_full | Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules |
| title_fullStr | Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules |
| title_full_unstemmed | Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules |
| title_short | Lanthanide-based metal–organic frameworks solidified by gelatin-methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules |
| title_sort | lanthanide based metal organic frameworks solidified by gelatin methacryloyl hydrogels for improving the accuracy of localization and excision of small pulmonary nodules |
| topic | Lanthanide-based metal–organic framework Gelatin-methacryloyl Localization of small pulmonary nodules Dual-modal imaging |
| url | https://doi.org/10.1186/s12951-022-01263-6 |
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