Novel NIR-II fluorescent probes for biliary atresia imaging
Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases. Therefore, it is...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523002551 |
| _version_ | 1797647928353882112 |
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| author | Xiaodong Zeng Yuqin Liao Xue Qiao Ke Liang Qiusi Luo Mingbo Deng Yishen Liu Weijing Zhang Xuechuan Hong Yuling Xiao |
| author_facet | Xiaodong Zeng Yuqin Liao Xue Qiao Ke Liang Qiusi Luo Mingbo Deng Yishen Liu Weijing Zhang Xuechuan Hong Yuling Xiao |
| author_sort | Xiaodong Zeng |
| collection | DOAJ |
| description | Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases. Therefore, it is very important to develop a simple, safe and reliable method for the early diagnosis of biliary atresia. Herein, a novel NIR-II fluorescence probe, HZL2, with high quantum yield, excellent biocompatibility, low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability. A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time, allowing for an early diagnosis of the disease. This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia. |
| first_indexed | 2024-03-11T15:24:44Z |
| format | Article |
| id | doaj.art-f3027c07a4ab4913ada166c4a6276470 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-11T15:24:44Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-f3027c07a4ab4913ada166c4a62764702023-10-28T05:07:01ZengElsevierActa Pharmaceutica Sinica B2211-38352023-11-01131145784590Novel NIR-II fluorescent probes for biliary atresia imagingXiaodong Zeng0Yuqin Liao1Xue Qiao2Ke Liang3Qiusi Luo4Mingbo Deng5Yishen Liu6Weijing Zhang7Xuechuan Hong8Yuling Xiao9State Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Shenzhen Institute of Wuhan University, Shenzhen 518057, China; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau, Ministry of Education, School of Ecology and Environment, Tibet University, Lhasa 850000, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Shenzhen Institute of Wuhan University, Shenzhen 518057, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China; School of Pharmacy, Yantai University, Yantai 264005, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau, Ministry of Education, School of Ecology and Environment, Tibet University, Lhasa 850000, China; Shenzhen Institute of Wuhan University, Shenzhen 518057, ChinaState Key Laboratory of Virology, Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China; Corresponding author.Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases. Therefore, it is very important to develop a simple, safe and reliable method for the early diagnosis of biliary atresia. Herein, a novel NIR-II fluorescence probe, HZL2, with high quantum yield, excellent biocompatibility, low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability. A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time, allowing for an early diagnosis of the disease. This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia.http://www.sciencedirect.com/science/article/pii/S2211383523002551Biliary atresiaFluorescence imagingSecond near-infrared windowEarly diagnosisHepatobiliary excretion |
| spellingShingle | Xiaodong Zeng Yuqin Liao Xue Qiao Ke Liang Qiusi Luo Mingbo Deng Yishen Liu Weijing Zhang Xuechuan Hong Yuling Xiao Novel NIR-II fluorescent probes for biliary atresia imaging Acta Pharmaceutica Sinica B Biliary atresia Fluorescence imaging Second near-infrared window Early diagnosis Hepatobiliary excretion |
| title | Novel NIR-II fluorescent probes for biliary atresia imaging |
| title_full | Novel NIR-II fluorescent probes for biliary atresia imaging |
| title_fullStr | Novel NIR-II fluorescent probes for biliary atresia imaging |
| title_full_unstemmed | Novel NIR-II fluorescent probes for biliary atresia imaging |
| title_short | Novel NIR-II fluorescent probes for biliary atresia imaging |
| title_sort | novel nir ii fluorescent probes for biliary atresia imaging |
| topic | Biliary atresia Fluorescence imaging Second near-infrared window Early diagnosis Hepatobiliary excretion |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523002551 |
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