A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema

Purpose: We report a case of laryngeal edema associated with the Vogt-Koyanagi-Harada (VKH) syndrome. Patient and Methods: A 32-year-old African-American female presented with a 12-day prodrome, including headache, tinnitus and shortness of breath, which preceded sudden photophobia and bilateral vis...

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Main Authors: Dimosthenis Mantopoulos, Brad W. deSilva, Colleen M. Cebulla
Format: Article
Language:English
Published: Karger Publishers 2014-11-01
Series:Case Reports in Ophthalmology
Subjects:
Online Access:http://www.karger.com/Article/FullText/369003
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author Dimosthenis Mantopoulos
Brad W. deSilva
Colleen M. Cebulla
author_facet Dimosthenis Mantopoulos
Brad W. deSilva
Colleen M. Cebulla
author_sort Dimosthenis Mantopoulos
collection DOAJ
description Purpose: We report a case of laryngeal edema associated with the Vogt-Koyanagi-Harada (VKH) syndrome. Patient and Methods: A 32-year-old African-American female presented with a 12-day prodrome, including headache, tinnitus and shortness of breath, which preceded sudden photophobia and bilateral visual loss. Examination and clinical testing were most consistent with VKH, and the patient improved with intravenous methylprednisolone therapy. Results: The patient had persistent dyspnea, which was out of proportion to chest CT findings and which was exacerbated during a recurrence of VKH. Flexible fiberoptic laryngoscopy with stroboscopy revealed diffuse laryngeal edema. Symptoms were alleviated with breathing exercises. Conclusions: Several autoimmune diseases may cause diffuse laryngeal edema. In this case, VKH was associated with the patient's glottic edema and dyspnea. We recommend that laryngeal edema be considered in the differential diagnosis for patients with dyspnea and VKH.
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spelling doaj.art-f303114429c04d1f90f83a4f1a6974c92022-12-21T19:28:06ZengKarger PublishersCase Reports in Ophthalmology1663-26992014-11-015336136410.1159/000369003369003A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal EdemaDimosthenis MantopoulosBrad W. deSilvaColleen M. CebullaPurpose: We report a case of laryngeal edema associated with the Vogt-Koyanagi-Harada (VKH) syndrome. Patient and Methods: A 32-year-old African-American female presented with a 12-day prodrome, including headache, tinnitus and shortness of breath, which preceded sudden photophobia and bilateral visual loss. Examination and clinical testing were most consistent with VKH, and the patient improved with intravenous methylprednisolone therapy. Results: The patient had persistent dyspnea, which was out of proportion to chest CT findings and which was exacerbated during a recurrence of VKH. Flexible fiberoptic laryngoscopy with stroboscopy revealed diffuse laryngeal edema. Symptoms were alleviated with breathing exercises. Conclusions: Several autoimmune diseases may cause diffuse laryngeal edema. In this case, VKH was associated with the patient's glottic edema and dyspnea. We recommend that laryngeal edema be considered in the differential diagnosis for patients with dyspnea and VKH.http://www.karger.com/Article/FullText/369003Vogt-Koyanagi-Harada syndromeLaryngeal edemaGlottic edemaAutoimmune diseaseLaryngoscopy
spellingShingle Dimosthenis Mantopoulos
Brad W. deSilva
Colleen M. Cebulla
A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
Case Reports in Ophthalmology
Vogt-Koyanagi-Harada syndrome
Laryngeal edema
Glottic edema
Autoimmune disease
Laryngoscopy
title A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_full A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_fullStr A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_full_unstemmed A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_short A Case of Vogt-Koyanagi-Harada Syndrome with Persistent Dyspnea Secondary to Laryngeal Edema
title_sort case of vogt koyanagi harada syndrome with persistent dyspnea secondary to laryngeal edema
topic Vogt-Koyanagi-Harada syndrome
Laryngeal edema
Glottic edema
Autoimmune disease
Laryngoscopy
url http://www.karger.com/Article/FullText/369003
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