O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

Abstract Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. One of the most common neurodegenerative diseases that exhibit aberrant redox signa...

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Bibliographic Details
Main Authors: Willayat Y. Wani, Xiaosen Ouyang, Gloria A. Benavides, Matthew Redmann, Stacey S. Cofield, John J. Shacka, John C. Chatham, Victor Darley-Usmar, Jianhua Zhang
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Brain
Subjects:
Autophagy
Parkinson’s disease
Proteasome
Rapamycin
α-synuclein
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s13041-017-0311-1

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