Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study.
The "accelerator hypothesis" predicts early onset of Type 1 diabetes (T1D) in heavier children. Studies testing direction of correlation between body mass index (BMI) and age at onset of T1D in different continental populations have reported differing results-inverse, direct, and neutral....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5391107?pdf=render |
| _version_ | 1811306041792528384 |
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| author | Arshad M Channanath Naser Elkum Dalia Al-Abdulrazzaq Jaakko Tuomilehto Azza Shaltout Thangavel Alphonse Thanaraj |
| author_facet | Arshad M Channanath Naser Elkum Dalia Al-Abdulrazzaq Jaakko Tuomilehto Azza Shaltout Thangavel Alphonse Thanaraj |
| author_sort | Arshad M Channanath |
| collection | DOAJ |
| description | The "accelerator hypothesis" predicts early onset of Type 1 diabetes (T1D) in heavier children. Studies testing direction of correlation between body mass index (BMI) and age at onset of T1D in different continental populations have reported differing results-inverse, direct, and neutral. Evaluating the correlation in diverse ethnic populations is required to generalize the accelerator hypothesis.The study cohort comprised 474 Kuwaiti children of Arab ethnicity diagnosed with T1D at age 6 to 18 years during 2011-2013. Age- and sex-adjusted BMI z-scores were calculated by comparing the BMI measured at diagnosis with Kuwaiti pediatric population reference data recorded during comparable time-period. Multiple linear regression and Pearson correlation analyses were performed.BMI z-score was seen inversely associated with onset age (r,-0.28; p-value<0.001). Children with BMI z-score>0 (i.e. BMI >national average) showed a stronger correlation (r,-0.38; p-value<0.001) than those with BMI z-score<0 (r,-0.19; p-value<0.001); the former group showed significantly lower mean onset age than the latter group (9.6±2.4 versus 10.5±2.7; p-value<0.001). Observed inverse correlation was consistent with that seen in Anglo-saxon, central european, caucasian, and white children while inconsistent with that seen in Indian, New Zealander, and Australian children.The accelerator hypothesis generalizes in Arab pediatric population from Kuwait. |
| first_indexed | 2024-04-13T08:37:14Z |
| format | Article |
| id | doaj.art-f30513a8a45f4599b5e208ee1cbd95bd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T08:37:14Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f30513a8a45f4599b5e208ee1cbd95bd2022-12-22T02:54:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017572810.1371/journal.pone.0175728Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study.Arshad M ChannanathNaser ElkumDalia Al-AbdulrazzaqJaakko TuomilehtoAzza ShaltoutThangavel Alphonse ThanarajThe "accelerator hypothesis" predicts early onset of Type 1 diabetes (T1D) in heavier children. Studies testing direction of correlation between body mass index (BMI) and age at onset of T1D in different continental populations have reported differing results-inverse, direct, and neutral. Evaluating the correlation in diverse ethnic populations is required to generalize the accelerator hypothesis.The study cohort comprised 474 Kuwaiti children of Arab ethnicity diagnosed with T1D at age 6 to 18 years during 2011-2013. Age- and sex-adjusted BMI z-scores were calculated by comparing the BMI measured at diagnosis with Kuwaiti pediatric population reference data recorded during comparable time-period. Multiple linear regression and Pearson correlation analyses were performed.BMI z-score was seen inversely associated with onset age (r,-0.28; p-value<0.001). Children with BMI z-score>0 (i.e. BMI >national average) showed a stronger correlation (r,-0.38; p-value<0.001) than those with BMI z-score<0 (r,-0.19; p-value<0.001); the former group showed significantly lower mean onset age than the latter group (9.6±2.4 versus 10.5±2.7; p-value<0.001). Observed inverse correlation was consistent with that seen in Anglo-saxon, central european, caucasian, and white children while inconsistent with that seen in Indian, New Zealander, and Australian children.The accelerator hypothesis generalizes in Arab pediatric population from Kuwait.http://europepmc.org/articles/PMC5391107?pdf=render |
| spellingShingle | Arshad M Channanath Naser Elkum Dalia Al-Abdulrazzaq Jaakko Tuomilehto Azza Shaltout Thangavel Alphonse Thanaraj Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study. PLoS ONE |
| title | Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study. |
| title_full | Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study. |
| title_fullStr | Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study. |
| title_full_unstemmed | Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study. |
| title_short | Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study. |
| title_sort | ethnic differences in association of high body mass index with early onset of type 1 diabetes arab ethnicity as case study |
| url | http://europepmc.org/articles/PMC5391107?pdf=render |
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