Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives
Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. S...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/12/1904 |
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| author | Francesco Borgia Federica Li Pomi Mario Vaccaro Clara Alessandrello Vincenzo Papa Sebastiano Gangemi |
| author_facet | Francesco Borgia Federica Li Pomi Mario Vaccaro Clara Alessandrello Vincenzo Papa Sebastiano Gangemi |
| author_sort | Francesco Borgia |
| collection | DOAJ |
| description | Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy. |
| first_indexed | 2024-03-09T17:16:47Z |
| format | Article |
| id | doaj.art-f3051497840e46f7b0b2d64fe2060afc |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T17:16:47Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f3051497840e46f7b0b2d64fe2060afc2023-11-24T13:35:25ZengMDPI AGBiomolecules2218-273X2022-12-011212190410.3390/biom12121904Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future PerspectivesFrancesco Borgia0Federica Li Pomi1Mario Vaccaro2Clara Alessandrello3Vincenzo Papa4Sebastiano Gangemi5Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyAtopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy.https://www.mdpi.com/2218-273X/12/12/1904atopic dermatitisoxidative stressphototherapyreactive oxygen speciesultravioletUVB |
| spellingShingle | Francesco Borgia Federica Li Pomi Mario Vaccaro Clara Alessandrello Vincenzo Papa Sebastiano Gangemi Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives Biomolecules atopic dermatitis oxidative stress phototherapy reactive oxygen species ultraviolet UVB |
| title | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
| title_full | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
| title_fullStr | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
| title_full_unstemmed | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
| title_short | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
| title_sort | oxidative stress and phototherapy in atopic dermatitis mechanisms role and future perspectives |
| topic | atopic dermatitis oxidative stress phototherapy reactive oxygen species ultraviolet UVB |
| url | https://www.mdpi.com/2218-273X/12/12/1904 |
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