Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique
Hypothesis: Alpha-mangostin (AMG) is a natural compound possessing strong antibacterial activity. Because of its poor water solubility, the formulations of AMG usually require high concentrations of solubilizers leading limitation for using in some clinical applications. Thus, the novel formulation...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019361250 |
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| author | Rathapon Asasutjarit Tunradee Meesomboon Pheeraphong Adulheem Siriporn Kittiwisut Papawee Sookdee Worada Samosornsuk Asira Fuongfuchat |
| author_facet | Rathapon Asasutjarit Tunradee Meesomboon Pheeraphong Adulheem Siriporn Kittiwisut Papawee Sookdee Worada Samosornsuk Asira Fuongfuchat |
| author_sort | Rathapon Asasutjarit |
| collection | DOAJ |
| description | Hypothesis: Alpha-mangostin (AMG) is a natural compound possessing strong antibacterial activity. Because of its poor water solubility, the formulations of AMG usually require high concentrations of solubilizers leading limitation for using in some clinical applications. Thus, the novel formulation of topical nanoemulsion (NE) containing AMG (AMG-NE) with optimal content of the oil phase and surfactants was developed. Experiments: AMG was extracted, purified and used as an active ingredient of AMG-NE. Blank NEs (NEs without AMG) with varying in contents of the oil phase and surfactants and AMG-NE were prepared by the ultrasonication technique. They were investigated their physicochemical properties including antibacterial activity against Staphyloccocus aureus and Propionibacterium acnes (which is recently renamed as Cutibacterium acnes). Findings: Blank NEs and AMG-NE had droplet size in a range of nanometer and negative value of zeta potential. The droplet size, polydispersity index and zeta potential of blank NEs were affected by formulation compositions and sonication intensities. AMG could be loaded into a representative Blank NE at a maximum concentration of 0.2% w/w and did not cause significant changes in physicochemical properties. AMG-NE showed the antibacterial activity against Staphyloccocus aureus and Propionibacterium acnes without toxicity to the skin cells. Therefore, AMG-NE had potential for using in a clinical study to investigate its efficacy and safety in patients. |
| first_indexed | 2024-12-10T06:11:44Z |
| format | Article |
| id | doaj.art-f305bb94d8e34481b9d59b494bccb472 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-10T06:11:44Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f305bb94d8e34481b9d59b494bccb4722022-12-22T01:59:32ZengElsevierHeliyon2405-84402019-09-0159e02465Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication techniqueRathapon Asasutjarit0Tunradee Meesomboon1Pheeraphong Adulheem2Siriporn Kittiwisut3Papawee Sookdee4Worada Samosornsuk5Asira Fuongfuchat6Novel Drug Delivery Systems Development Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani, 12120, Thailand; Corresponding author.Novel Drug Delivery Systems Development Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani, 12120, ThailandNovel Drug Delivery Systems Development Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani, 12120, ThailandMedical Chemistry and Natural Products Research Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani, 12120, ThailandDepartment of Applied Thai Traditional Medicine, College of Allied Health Sciences, Suan Sunandha Rajabhat University, Samut Songkhram, 75000, ThailandDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, 12120, ThailandNational Metal and Materials Technology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, ThailandHypothesis: Alpha-mangostin (AMG) is a natural compound possessing strong antibacterial activity. Because of its poor water solubility, the formulations of AMG usually require high concentrations of solubilizers leading limitation for using in some clinical applications. Thus, the novel formulation of topical nanoemulsion (NE) containing AMG (AMG-NE) with optimal content of the oil phase and surfactants was developed. Experiments: AMG was extracted, purified and used as an active ingredient of AMG-NE. Blank NEs (NEs without AMG) with varying in contents of the oil phase and surfactants and AMG-NE were prepared by the ultrasonication technique. They were investigated their physicochemical properties including antibacterial activity against Staphyloccocus aureus and Propionibacterium acnes (which is recently renamed as Cutibacterium acnes). Findings: Blank NEs and AMG-NE had droplet size in a range of nanometer and negative value of zeta potential. The droplet size, polydispersity index and zeta potential of blank NEs were affected by formulation compositions and sonication intensities. AMG could be loaded into a representative Blank NE at a maximum concentration of 0.2% w/w and did not cause significant changes in physicochemical properties. AMG-NE showed the antibacterial activity against Staphyloccocus aureus and Propionibacterium acnes without toxicity to the skin cells. Therefore, AMG-NE had potential for using in a clinical study to investigate its efficacy and safety in patients.http://www.sciencedirect.com/science/article/pii/S2405844019361250Infectious diseasePhysical chemistryPharmaceutical chemistryPharmacologyMaterials safetyUltrasonication |
| spellingShingle | Rathapon Asasutjarit Tunradee Meesomboon Pheeraphong Adulheem Siriporn Kittiwisut Papawee Sookdee Worada Samosornsuk Asira Fuongfuchat Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique Heliyon Infectious disease Physical chemistry Pharmaceutical chemistry Pharmacology Materials safety Ultrasonication |
| title | Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique |
| title_full | Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique |
| title_fullStr | Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique |
| title_full_unstemmed | Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique |
| title_short | Physicochemical properties of alpha-mangostin loaded nanomeulsions prepared by ultrasonication technique |
| title_sort | physicochemical properties of alpha mangostin loaded nanomeulsions prepared by ultrasonication technique |
| topic | Infectious disease Physical chemistry Pharmaceutical chemistry Pharmacology Materials safety Ultrasonication |
| url | http://www.sciencedirect.com/science/article/pii/S2405844019361250 |
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