Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study
BackgroundHearing loss (HL) may increase the risk of cognitive decline in the elderly. However, the randomized controlled study on the effect of HL on cognitive function in mild cognitive impairment (MCI) is very limited.MethodsFrom 1 November 2020 to 30 March 2022, 1,987 individuals aged 55–65 year...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.934921/full |
| _version_ | 1818018301829185536 |
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| author | Jie Tong Jie Zhang Luli Xu Meiling Liu Jie Min Miaomiao Yao Xiaoyan Cheng Qi Zhang Xirong Sun Jie Yuan |
| author_facet | Jie Tong Jie Zhang Luli Xu Meiling Liu Jie Min Miaomiao Yao Xiaoyan Cheng Qi Zhang Xirong Sun Jie Yuan |
| author_sort | Jie Tong |
| collection | DOAJ |
| description | BackgroundHearing loss (HL) may increase the risk of cognitive decline in the elderly. However, the randomized controlled study on the effect of HL on cognitive function in mild cognitive impairment (MCI) is very limited.MethodsFrom 1 November 2020 to 30 March 2022, 1,987 individuals aged 55–65 years were randomly divided into the MCI with hearing impairment (MCI-HI), MCI without HI (MCI-nHI), and no MCI (nMCI) groups by stratified sampling, with 30 participants in each group. The Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the pure tone audiometry (PTA), and the auditory brainstem response (ABR) were measured at baseline and a follow-up 12 months later. The trial protocol was registered with ClinicalTrials.gov with the registration number NCT05336942.ResultsAmong the 90 participants, the average age was 60.41 ± 6.48 years. In the MCI-HI group at baseline, the PTA score of both the ears was negatively correlated with the naming and memory score (p < 0.05), and the PTA score of both the ears was negatively correlated with the MoCA and abstraction score at the 12-month follow-up (p < 0.05). However, there were no significant differences among the PTA, the ABR, the MMSE, and the MoCA scores in the MCI-nHI and nMCI groups (p > 0.05). Regression analysis showed that the PTA score of the right ear at baseline was an important factor associated with the MoCA, visuospatial/executive, naming, and abstraction scores at the 12-month follow-up (β = −0.776 to −0.422, p < 0.05).ConclusionHL was significantly negatively associated with cognitive function only in patients with MCI with hearing impairment (HI), and the PTA of the right ear may be a predictor of cognitive decline after 1 year in patients with MCI with HI. This information may help primary healthcare clinicians to prevent MCI by screening and intervening in care for elderly patients with HL. |
| first_indexed | 2024-04-14T07:38:08Z |
| format | Article |
| id | doaj.art-f305c322f3aa4ceca25e4c41a86f2e1d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-14T07:38:08Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f305c322f3aa4ceca25e4c41a86f2e1d2022-12-22T02:05:38ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.934921934921Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled studyJie Tong0Jie Zhang1Luli Xu2Meiling Liu3Jie Min4Miaomiao Yao5Xiaoyan Cheng6Qi Zhang7Xirong Sun8Jie Yuan9Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Otolaryngology, Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, ChinaBackgroundHearing loss (HL) may increase the risk of cognitive decline in the elderly. However, the randomized controlled study on the effect of HL on cognitive function in mild cognitive impairment (MCI) is very limited.MethodsFrom 1 November 2020 to 30 March 2022, 1,987 individuals aged 55–65 years were randomly divided into the MCI with hearing impairment (MCI-HI), MCI without HI (MCI-nHI), and no MCI (nMCI) groups by stratified sampling, with 30 participants in each group. The Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the pure tone audiometry (PTA), and the auditory brainstem response (ABR) were measured at baseline and a follow-up 12 months later. The trial protocol was registered with ClinicalTrials.gov with the registration number NCT05336942.ResultsAmong the 90 participants, the average age was 60.41 ± 6.48 years. In the MCI-HI group at baseline, the PTA score of both the ears was negatively correlated with the naming and memory score (p < 0.05), and the PTA score of both the ears was negatively correlated with the MoCA and abstraction score at the 12-month follow-up (p < 0.05). However, there were no significant differences among the PTA, the ABR, the MMSE, and the MoCA scores in the MCI-nHI and nMCI groups (p > 0.05). Regression analysis showed that the PTA score of the right ear at baseline was an important factor associated with the MoCA, visuospatial/executive, naming, and abstraction scores at the 12-month follow-up (β = −0.776 to −0.422, p < 0.05).ConclusionHL was significantly negatively associated with cognitive function only in patients with MCI with hearing impairment (HI), and the PTA of the right ear may be a predictor of cognitive decline after 1 year in patients with MCI with HI. This information may help primary healthcare clinicians to prevent MCI by screening and intervening in care for elderly patients with HL.https://www.frontiersin.org/articles/10.3389/fnagi.2022.934921/fullhearing losscognitive functionmild cognitive impairmentMCIHL |
| spellingShingle | Jie Tong Jie Zhang Luli Xu Meiling Liu Jie Min Miaomiao Yao Xiaoyan Cheng Qi Zhang Xirong Sun Jie Yuan Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study Frontiers in Aging Neuroscience hearing loss cognitive function mild cognitive impairment MCI HL |
| title | Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study |
| title_full | Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study |
| title_fullStr | Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study |
| title_full_unstemmed | Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study |
| title_short | Effect of hearing loss on cognitive function in patients with mild cognitive impairment: A prospective, randomized, and controlled study |
| title_sort | effect of hearing loss on cognitive function in patients with mild cognitive impairment a prospective randomized and controlled study |
| topic | hearing loss cognitive function mild cognitive impairment MCI HL |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.934921/full |
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