A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging
Aim: To compare the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging procedures. Methods: Sixty children between the age of 1 to 7 years were randomly distributed into two groups: The dexmedetomidine (D) group received 1...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Saudi Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2011;volume=5;issue=3;spage=295;epage=299;aulast=Dave |
| _version_ | 1819006912983728128 |
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| author | Jaydev Dave Sandip Vaghela |
| author_facet | Jaydev Dave Sandip Vaghela |
| author_sort | Jaydev Dave |
| collection | DOAJ |
| description | Aim: To compare the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging procedures. Methods: Sixty children between the age of 1 to 7 years were randomly distributed into two groups: The dexmedetomidine (D) group received 1 μg/kg initial dose followed by continuous infusion of 0.5 μg/kg/h, and the propofol group (P) received 3 mg/kg initial dose, followed by a continuous infusion of 100 μg/kg/min. Inadequate sedation was defined as difficulty in completing the procedure because of the child′s movement during magnetic resonance imaging. Mean arterial pressure (MAP), heart rate, peripheral oxygen saturation, and respiratory rate (RR) were recorded during the study. Result: The onset of sedation, recovery, and discharge time were significantly shorter in group P than in group D. MAP, heart rate, and RR decreased during sedation from the baseline values in both groups. MAP and RR were significantly lower in group P than in group D during sedation. Dexmedetomidine and propofol provided adequate sedation in most of the children. Conclusion: We conclude that although propofol provided faster anesthetic induction and recovery times, it caused hypotension and desaturation. Dexmedetomidine could be an alternative, reliable sedative drug to propofol in selected patients. |
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| id | doaj.art-f3061156eb5d4314ad1a3cbf30266ba6 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-12-21T00:16:14Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-f3061156eb5d4314ad1a3cbf30266ba62022-12-21T19:22:13ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2011-01-015329529910.4103/1658-354X.84105A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imagingJaydev DaveSandip VaghelaAim: To compare the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging procedures. Methods: Sixty children between the age of 1 to 7 years were randomly distributed into two groups: The dexmedetomidine (D) group received 1 μg/kg initial dose followed by continuous infusion of 0.5 μg/kg/h, and the propofol group (P) received 3 mg/kg initial dose, followed by a continuous infusion of 100 μg/kg/min. Inadequate sedation was defined as difficulty in completing the procedure because of the child′s movement during magnetic resonance imaging. Mean arterial pressure (MAP), heart rate, peripheral oxygen saturation, and respiratory rate (RR) were recorded during the study. Result: The onset of sedation, recovery, and discharge time were significantly shorter in group P than in group D. MAP, heart rate, and RR decreased during sedation from the baseline values in both groups. MAP and RR were significantly lower in group P than in group D during sedation. Dexmedetomidine and propofol provided adequate sedation in most of the children. Conclusion: We conclude that although propofol provided faster anesthetic induction and recovery times, it caused hypotension and desaturation. Dexmedetomidine could be an alternative, reliable sedative drug to propofol in selected patients.http://www.saudija.org/article.asp?issn=1658-354X;year=2011;volume=5;issue=3;spage=295;epage=299;aulast=DaveDexmedetomidinemagnetic resonance imagingpropofol |
| spellingShingle | Jaydev Dave Sandip Vaghela A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging Saudi Journal of Anaesthesia Dexmedetomidine magnetic resonance imaging propofol |
| title | A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging |
| title_full | A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging |
| title_fullStr | A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging |
| title_full_unstemmed | A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging |
| title_short | A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging |
| title_sort | comparison of the sedative hemodynamic and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging |
| topic | Dexmedetomidine magnetic resonance imaging propofol |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2011;volume=5;issue=3;spage=295;epage=299;aulast=Dave |
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