Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance
Benign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH are yet not devoid of side effects. Herbal compounds are suggested to be an alternative option for the BPH treatment. In our study, we evalua...
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2021-12-01
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| author | Alexander L. Semenov Ekaterina A. Gubareva Elena D. Ermakova Anastasia A. Dorofeeva Irina A. Tumanyan Ekaterina A. Radetskaya Maria N. Yurova Saied A. Aboushanab Osman N. Kanwugu Elena I. Fedoros Andrey V. Panchenko |
| author_facet | Alexander L. Semenov Ekaterina A. Gubareva Elena D. Ermakova Anastasia A. Dorofeeva Irina A. Tumanyan Ekaterina A. Radetskaya Maria N. Yurova Saied A. Aboushanab Osman N. Kanwugu Elena I. Fedoros Andrey V. Panchenko |
| author_sort | Alexander L. Semenov |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH are yet not devoid of side effects. Herbal compounds are suggested to be an alternative option for the BPH treatment. In our study, we evaluated the effect of kudzu isoflavones and astaxanthin on the BPH animal model. The animals were randomly divided into five groups: control; testosterone-induced BPH group; and three BPH-induced groups, which received intragastrically for 28 days finasteride (5 mg/kg) as a positive control, isoflavones (200 mg/kg), and astaxanthin (25 mg/kg). BPH was induced by castration of animals and subsequent subcutaneous injections of prolonged testosterone (25 mg/kg). Prostate index and histology, biochemical parameters, and antioxidant activity were evaluated. A significant decrease in prostate weight, immunohistochemical markers, and normalization of prostate Ca/Mg ratio was found in all treatment groups. Astaxanthin treatment also resulted in decreased epithelial proliferation and normalized superoxide dismutase activity. In conclusion, both isoflavones and astaxanthin inhibited BPH development at a level comparable to finasteride in terms of prostate weight, prostatic epithelium proliferation, and prostate tissue cumulative histology score. These results suggest that isoflavones and especially astaxanthin could serve as a potential alternative therapy to treat BHP. |
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| spelling | doaj.art-f3072238881441b8a602ab97fca6d49d2023-11-23T10:12:25ZengMDPI AGPlants2223-77472021-12-011012273510.3390/plants10122735Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg BalanceAlexander L. Semenov0Ekaterina A. Gubareva1Elena D. Ermakova2Anastasia A. Dorofeeva3Irina A. Tumanyan4Ekaterina A. Radetskaya5Maria N. Yurova6Saied A. Aboushanab7Osman N. Kanwugu8Elena I. Fedoros9Andrey V. Panchenko10N.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaInstitute of Chemical Technology, Ural Federal University Named after The First President of Russia B. N. Yeltsin, Mira 19, 620002 Yekaterinburg, RussiaInstitute of Chemical Technology, Ural Federal University Named after The First President of Russia B. N. Yeltsin, Mira 19, 620002 Yekaterinburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaN.N. Petrov National Medical Research Center of Oncology, Leningradskaya str, 68, 197758 St. Petersburg, RussiaBenign prostatic hyperplasia (BPH) is a common pathology among aging men. Despite the broad pharmacological interventions, the available remedies to treat BPH are yet not devoid of side effects. Herbal compounds are suggested to be an alternative option for the BPH treatment. In our study, we evaluated the effect of kudzu isoflavones and astaxanthin on the BPH animal model. The animals were randomly divided into five groups: control; testosterone-induced BPH group; and three BPH-induced groups, which received intragastrically for 28 days finasteride (5 mg/kg) as a positive control, isoflavones (200 mg/kg), and astaxanthin (25 mg/kg). BPH was induced by castration of animals and subsequent subcutaneous injections of prolonged testosterone (25 mg/kg). Prostate index and histology, biochemical parameters, and antioxidant activity were evaluated. A significant decrease in prostate weight, immunohistochemical markers, and normalization of prostate Ca/Mg ratio was found in all treatment groups. Astaxanthin treatment also resulted in decreased epithelial proliferation and normalized superoxide dismutase activity. In conclusion, both isoflavones and astaxanthin inhibited BPH development at a level comparable to finasteride in terms of prostate weight, prostatic epithelium proliferation, and prostate tissue cumulative histology score. These results suggest that isoflavones and especially astaxanthin could serve as a potential alternative therapy to treat BHP.https://www.mdpi.com/2223-7747/10/12/2735benign prostatic hyperplasiatestosteroneisoflavonesastaxanthinmagnesiumcalcium |
| spellingShingle | Alexander L. Semenov Ekaterina A. Gubareva Elena D. Ermakova Anastasia A. Dorofeeva Irina A. Tumanyan Ekaterina A. Radetskaya Maria N. Yurova Saied A. Aboushanab Osman N. Kanwugu Elena I. Fedoros Andrey V. Panchenko Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance Plants benign prostatic hyperplasia testosterone isoflavones astaxanthin magnesium calcium |
| title | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance |
| title_full | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance |
| title_fullStr | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance |
| title_full_unstemmed | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance |
| title_short | Astaxantin and Isoflavones Inhibit Benign Prostatic Hyperplasia in Rats by Reducing Oxidative Stress and Normalizing Ca/Mg Balance |
| title_sort | astaxantin and isoflavones inhibit benign prostatic hyperplasia in rats by reducing oxidative stress and normalizing ca mg balance |
| topic | benign prostatic hyperplasia testosterone isoflavones astaxanthin magnesium calcium |
| url | https://www.mdpi.com/2223-7747/10/12/2735 |
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