Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data
In Japan, pivoxil-conjugated antibodies (PVs) are commonly used to treat infections. However, carnitine deficiency is a known adverse drug reaction associated with PV treatment. This study aimed to research the practical use of PV and assess the risk of carnitine deficiency in patients receiving PV...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/11/2/150 |
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| author | Kaho Suzuki-Yoshida Kosuke Nakano Masayoshi Nakakuni Naoko Deguchi Seiji Mitsui Shinji Kobayashi Akimasa Yamatani Miki Akabane |
| author_facet | Kaho Suzuki-Yoshida Kosuke Nakano Masayoshi Nakakuni Naoko Deguchi Seiji Mitsui Shinji Kobayashi Akimasa Yamatani Miki Akabane |
| author_sort | Kaho Suzuki-Yoshida |
| collection | DOAJ |
| description | In Japan, pivoxil-conjugated antibodies (PVs) are commonly used to treat infections. However, carnitine deficiency is a known adverse drug reaction associated with PV treatment. This study aimed to research the practical use of PV and assess the risk of carnitine deficiency in patients receiving PV compared to their amoxicillin (AM)-treated counterparts. The Pediatric Medical Information Collection System (P-MICS) served as the data source for this study. The study cohort comprised patients aged 0–15 years prescribed PV between April 2016 and March 2021. Data on the actual PV prescriptions were extracted for each patient. To evaluate the risk of carnitine deficiency, adverse events (AEs) were defined as carnitine deficiency and its associated symptoms. Propensity score matching was employed to compare the AE incidence between the PV and AM groups. The number of cases of PV prescriptions decreased year-on-year between 2016 and 2021, and >80% of prescriptions were dispensed in the clinic. The propensity score matching analysis demonstrated no statistically significant difference in the incidence of carnitine deficiency and its associated symptoms between the PV and AM groups. Our findings suggest that the risk of carnitine deficiency in children treated with PV is not significantly higher than that associated with other antibiotics. |
| first_indexed | 2024-03-07T22:38:14Z |
| format | Article |
| id | doaj.art-f3087ed5280143ce833ea5b8c2be299d |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-07T22:38:14Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f3087ed5280143ce833ea5b8c2be299d2024-02-23T15:12:12ZengMDPI AGChildren2227-90672024-01-0111215010.3390/children11020150Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World DataKaho Suzuki-Yoshida0Kosuke Nakano1Masayoshi Nakakuni2Naoko Deguchi3Seiji Mitsui4Shinji Kobayashi5Akimasa Yamatani6Miki Akabane7Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, Tokyo 204-0004, JapanClinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, JapanClinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, JapanClinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, JapanClinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, JapanNature Insight Co., Ltd., Tokyo 101-0021, JapanGraduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, Tokyo 204-0004, JapanGraduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, Tokyo 204-0004, JapanIn Japan, pivoxil-conjugated antibodies (PVs) are commonly used to treat infections. However, carnitine deficiency is a known adverse drug reaction associated with PV treatment. This study aimed to research the practical use of PV and assess the risk of carnitine deficiency in patients receiving PV compared to their amoxicillin (AM)-treated counterparts. The Pediatric Medical Information Collection System (P-MICS) served as the data source for this study. The study cohort comprised patients aged 0–15 years prescribed PV between April 2016 and March 2021. Data on the actual PV prescriptions were extracted for each patient. To evaluate the risk of carnitine deficiency, adverse events (AEs) were defined as carnitine deficiency and its associated symptoms. Propensity score matching was employed to compare the AE incidence between the PV and AM groups. The number of cases of PV prescriptions decreased year-on-year between 2016 and 2021, and >80% of prescriptions were dispensed in the clinic. The propensity score matching analysis demonstrated no statistically significant difference in the incidence of carnitine deficiency and its associated symptoms between the PV and AM groups. Our findings suggest that the risk of carnitine deficiency in children treated with PV is not significantly higher than that associated with other antibiotics.https://www.mdpi.com/2227-9067/11/2/150pivoxil-conjugated antibodiesreal-world datachildrencarnitine deficiency |
| spellingShingle | Kaho Suzuki-Yoshida Kosuke Nakano Masayoshi Nakakuni Naoko Deguchi Seiji Mitsui Shinji Kobayashi Akimasa Yamatani Miki Akabane Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data Children pivoxil-conjugated antibodies real-world data children carnitine deficiency |
| title | Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data |
| title_full | Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data |
| title_fullStr | Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data |
| title_full_unstemmed | Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data |
| title_short | Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the Risk of Carnitine Deficiency Using Real-World Data |
| title_sort | research on the clinical practical use of pivoxil conjugated antibodies and the risk of carnitine deficiency using real world data |
| topic | pivoxil-conjugated antibodies real-world data children carnitine deficiency |
| url | https://www.mdpi.com/2227-9067/11/2/150 |
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