miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone

miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone

Summary: Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling. Mice with deletion of miR-29cb2 exhibit osteopenic phenotypes and...

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Bibliographic Details
Main Authors: Liping Ouyang, Yingxiao Sun, Dan Lv, Xiaochun Peng, Xiaoming Liu, Lei Ci, Guoning Zhang, Bo Yuan, Ling Li, Jian Fei, Jun Ma, Xuanyong Liu, Yun Liao
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Molecular biology
Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221015741

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