The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain
There is increasing recognition of the involvement of the nigrostriatal and mesolimbic dopamine systems in the modulation of chronic pain. The first part of the present article reviews the evidence indicating that dopamine exerts analgesic effects during persistent pain by stimulating the D2 recepto...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/10/1311 |
| _version_ | 1797515185958682624 |
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| author | Barbara Ziółkowska |
| author_facet | Barbara Ziółkowska |
| author_sort | Barbara Ziółkowska |
| collection | DOAJ |
| description | There is increasing recognition of the involvement of the nigrostriatal and mesolimbic dopamine systems in the modulation of chronic pain. The first part of the present article reviews the evidence indicating that dopamine exerts analgesic effects during persistent pain by stimulating the D2 receptors in the dorsal striatum and nucleus accumbens (NAc). Thereby, dopamine inhibits striatal output via the D2 receptor-expressing medium spiny neurons (D2-MSN). Dopaminergic neurotransmission in the mesostriatal pathways is hampered in chronic pain states and this alteration maintains and exacerbates pain. The second part of this article focuses on the glutamatergic inputs from the medial prefrontal cortex to the NAc, their activity changes in chronic pain, and their role in pain modulation. Finally, interactions between dopaminergic and glutamatergic inputs to the D2-MSN are considered in the context of persistent pain. Studies using novel techniques indicate that pain is regulated oppositely by two independent dopaminergic circuits linking separate parts of the ventral tegmental area and of the NAc, which also interact with distinct regions of the medial prefrontal cortex. |
| first_indexed | 2024-03-10T06:41:57Z |
| format | Article |
| id | doaj.art-f30c4044a51245ef92c3eaf25cf5d56e |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T06:41:57Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f30c4044a51245ef92c3eaf25cf5d56e2023-11-22T17:37:13ZengMDPI AGBrain Sciences2076-34252021-10-011110131110.3390/brainsci11101311The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic PainBarbara Ziółkowska0Department of Molecular Neuropharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, PolandThere is increasing recognition of the involvement of the nigrostriatal and mesolimbic dopamine systems in the modulation of chronic pain. The first part of the present article reviews the evidence indicating that dopamine exerts analgesic effects during persistent pain by stimulating the D2 receptors in the dorsal striatum and nucleus accumbens (NAc). Thereby, dopamine inhibits striatal output via the D2 receptor-expressing medium spiny neurons (D2-MSN). Dopaminergic neurotransmission in the mesostriatal pathways is hampered in chronic pain states and this alteration maintains and exacerbates pain. The second part of this article focuses on the glutamatergic inputs from the medial prefrontal cortex to the NAc, their activity changes in chronic pain, and their role in pain modulation. Finally, interactions between dopaminergic and glutamatergic inputs to the D2-MSN are considered in the context of persistent pain. Studies using novel techniques indicate that pain is regulated oppositely by two independent dopaminergic circuits linking separate parts of the ventral tegmental area and of the NAc, which also interact with distinct regions of the medial prefrontal cortex.https://www.mdpi.com/2076-3425/11/10/1311paindopaminestriatumnucleus accumbenscorticostriatalmedial prefrontal cortex |
| spellingShingle | Barbara Ziółkowska The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain Brain Sciences pain dopamine striatum nucleus accumbens corticostriatal medial prefrontal cortex |
| title | The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain |
| title_full | The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain |
| title_fullStr | The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain |
| title_full_unstemmed | The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain |
| title_short | The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain |
| title_sort | role of mesostriatal dopamine system and corticostriatal glutamatergic transmission in chronic pain |
| topic | pain dopamine striatum nucleus accumbens corticostriatal medial prefrontal cortex |
| url | https://www.mdpi.com/2076-3425/11/10/1311 |
| work_keys_str_mv | AT barbaraziołkowska theroleofmesostriataldopaminesystemandcorticostriatalglutamatergictransmissioninchronicpain AT barbaraziołkowska roleofmesostriataldopaminesystemandcorticostriatalglutamatergictransmissioninchronicpain |