Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d
Cas13d is a class 2 type VI-D CRISPR-Cas RNA-guided RNase. Here the authors present the high-resolution crystal structure of the uncultured Ruminococcus sp. Cas13d (UrCas13d)-crRNA complex and by combining structural, mutational and biochemical studies provide mechanistic insights into the CRISPR-Ca...
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Bibliographic Details
| Main Authors: |
Bo Zhang,
Yangmiao Ye,
Weiwei Ye,
Vanja Perčulija,
Han Jiang,
Yiyang Chen,
Yu Li,
Jing Chen,
Jinying Lin,
Siqi Wang,
Qi Chen,
Yu-San Han,
Songying Ouyang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-10507-3
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