Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases
The function and structure of the mammalian epithelial cell layer is maintained by distinct intercellular adhesion complexes including adherens junctions (AJs), tight junctions, and desmosomes. The AJ is most integral for stabilizing cell-cell adhesion and conserving the structural integrity of epit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.998373/full |
| _version_ | 1828341202525618176 |
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| author | Lindyann R. Lessey Shaiya C. Robinson Roopali Chaudhary Juliet M. Daniel |
| author_facet | Lindyann R. Lessey Shaiya C. Robinson Roopali Chaudhary Juliet M. Daniel |
| author_sort | Lindyann R. Lessey |
| collection | DOAJ |
| description | The function and structure of the mammalian epithelial cell layer is maintained by distinct intercellular adhesion complexes including adherens junctions (AJs), tight junctions, and desmosomes. The AJ is most integral for stabilizing cell-cell adhesion and conserving the structural integrity of epithelial tissues. AJs are comprised of the transmembrane protein E-cadherin and cytoplasmic catenin cofactors (α, β, γ, and p120-catenin). One organ where malfunction of AJ is a major contributor to disease states is the mammalian intestine. In the intestine, cell-cell adhesion complexes work synergistically to maintain structural integrity and homeostasis of the epithelium and prevent its malfunction. Consequently, when AJ integrity is compromised in the intestinal epithelium, the ensuing homeostatic disruption leads to diseases such as inflammatory bowel disease and colorectal carcinoma. In addition to their function at the plasma membrane, protein components of AJs also have nuclear functions and are thus implicated in regulating gene expression and intracellular signaling. Within the nucleus, AJ proteins have been shown to interact with transcription factors such as TCF/LEF and Kaiso (ZBTB33), which converge on the canonical Wnt signaling pathway. The multifaceted nature of AJ proteins highlights their complexity in modulating homeostasis and emphasizes the importance of their subcellular localization and expression in the mammalian intestine. In this review, we summarize the nuclear roles of AJ proteins in intestinal tissues; their interactions with transcription factors and how this leads to crosstalk with canonical Wnt signaling; and how nuclear AJ proteins are implicated in intestinal homeostasis and disease. |
| first_indexed | 2024-04-13T23:09:07Z |
| format | Article |
| id | doaj.art-f30e978c1a85413a8c825a90b43b3883 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T23:09:07Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-f30e978c1a85413a8c825a90b43b38832022-12-22T02:25:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-10-011010.3389/fcell.2022.998373998373Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseasesLindyann R. LesseyShaiya C. RobinsonRoopali ChaudharyJuliet M. DanielThe function and structure of the mammalian epithelial cell layer is maintained by distinct intercellular adhesion complexes including adherens junctions (AJs), tight junctions, and desmosomes. The AJ is most integral for stabilizing cell-cell adhesion and conserving the structural integrity of epithelial tissues. AJs are comprised of the transmembrane protein E-cadherin and cytoplasmic catenin cofactors (α, β, γ, and p120-catenin). One organ where malfunction of AJ is a major contributor to disease states is the mammalian intestine. In the intestine, cell-cell adhesion complexes work synergistically to maintain structural integrity and homeostasis of the epithelium and prevent its malfunction. Consequently, when AJ integrity is compromised in the intestinal epithelium, the ensuing homeostatic disruption leads to diseases such as inflammatory bowel disease and colorectal carcinoma. In addition to their function at the plasma membrane, protein components of AJs also have nuclear functions and are thus implicated in regulating gene expression and intracellular signaling. Within the nucleus, AJ proteins have been shown to interact with transcription factors such as TCF/LEF and Kaiso (ZBTB33), which converge on the canonical Wnt signaling pathway. The multifaceted nature of AJ proteins highlights their complexity in modulating homeostasis and emphasizes the importance of their subcellular localization and expression in the mammalian intestine. In this review, we summarize the nuclear roles of AJ proteins in intestinal tissues; their interactions with transcription factors and how this leads to crosstalk with canonical Wnt signaling; and how nuclear AJ proteins are implicated in intestinal homeostasis and disease.https://www.frontiersin.org/articles/10.3389/fcell.2022.998373/fullAdherens JunctionE-cadherincateninsKaisoWnt signalinginflammatory bowel disease |
| spellingShingle | Lindyann R. Lessey Shaiya C. Robinson Roopali Chaudhary Juliet M. Daniel Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases Frontiers in Cell and Developmental Biology Adherens Junction E-cadherin catenins Kaiso Wnt signaling inflammatory bowel disease |
| title | Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases |
| title_full | Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases |
| title_fullStr | Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases |
| title_full_unstemmed | Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases |
| title_short | Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases |
| title_sort | adherens junction proteins on the move from the membrane to the nucleus in intestinal diseases |
| topic | Adherens Junction E-cadherin catenins Kaiso Wnt signaling inflammatory bowel disease |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.998373/full |
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