Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial
Abstract Introduction Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome (MS)-related liver disorder that has an increasing prevalence. Thus, the aim of our study is to evaluate the effects of pomegranate peel extract (PP) supplementation on hepatic status and metabolic syndrome risk...
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| Format: | Article |
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BMC
2023-08-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-023-00869-2 |
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| author | Hanieh Barghchi Narges Milkarizi Saba Belyani Andisheh Norouzian Ostad Vahid Reza Askari Farnood Rajabzadeh Ladan Goshayeshi Seyede Yegane Ghelichi Kheyrabadi Maryam Razavidarmian Zahra Dehnavi Seyyed Reza Sobhani Mohsen Nematy |
| author_facet | Hanieh Barghchi Narges Milkarizi Saba Belyani Andisheh Norouzian Ostad Vahid Reza Askari Farnood Rajabzadeh Ladan Goshayeshi Seyede Yegane Ghelichi Kheyrabadi Maryam Razavidarmian Zahra Dehnavi Seyyed Reza Sobhani Mohsen Nematy |
| author_sort | Hanieh Barghchi |
| collection | DOAJ |
| description | Abstract Introduction Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome (MS)-related liver disorder that has an increasing prevalence. Thus, the aim of our study is to evaluate the effects of pomegranate peel extract (PP) supplementation on hepatic status and metabolic syndrome risk factors. Methods In phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. Then, in phase two, NAFLD patients received 1500 mg of placebo (n = 37) or pomegranate peel capsules (n = 39) with a 500-kcal deficit diet for 8 weeks. Gastrointestinal intolerance, dietary intake, lipid and glycemic profiles, systolic and diastolic blood pressure, body composition, insulin resistance indexes, and elastography-evaluated NAFLD changes were followed. Results The mean age of participants was 43.1 ± 8.6 years (51.3% female). Following the intervention, the mean body weight (mean changes: -5.10 ± 2.30 kg), waist circumference (-7.57 ± 2.97 cm), body mass index (-1.82 ± 0.85 kg/m2), body fat index (-1.49 ± 0.86), and trunk fat (− 3.93 ± 3.07%), systolic (-0.63 ± 0.29 cmHg) and diastolic (-0.39 ± 0.19 cmHg) blood pressure, total cholesterol (-10.51 ± 0.77 mg/dl), triglyceride (-16.02 ± 1.7 mg/dl), low-density lipoprotein cholesterol (-9.33 ± 6.66 mg/dl; all P < 0.001), fat free mass (− 0.92 ± 0.90 kg; P < 0.003), and fasting blood sugar (-5.28 ± 1.36 mg/dl; P = 0.02) decreased significantly in PP in contrast to the placebo group in the raw model and when adjusted for confounders. Also, high-density lipoprotein cholesterol (5.10 ± 0.36 mg/dl), liver steatosis and stiffness (− 0.30 ± 0.17 and − 0.72 ± 0.35 kPa, respectively, all P < 0.001) improved in the PP group. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw and even adjusted models. Conclusion In conclusion, 1500 mg pomegranate peel extract along with a weight-loss diet improved metabolic syndrome risk factors and reduced hepatic steatosis in patients with NAFLD after 8 weeks. |
| first_indexed | 2024-03-10T22:16:54Z |
| format | Article |
| id | doaj.art-f3129d2ea9614652a237a668f3d604ec |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-03-10T22:16:54Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-f3129d2ea9614652a237a668f3d604ec2023-11-19T12:26:45ZengBMCNutrition Journal1475-28912023-08-0122111710.1186/s12937-023-00869-2Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trialHanieh Barghchi0Narges Milkarizi1Saba Belyani2Andisheh Norouzian Ostad3Vahid Reza Askari4Farnood Rajabzadeh5Ladan Goshayeshi6Seyede Yegane Ghelichi Kheyrabadi7Maryam Razavidarmian8Zahra Dehnavi9Seyyed Reza Sobhani10Mohsen Nematy11Department of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesMetabolic Syndrome Research Center, Department of Nutrition, School of Medicine, Mashhad University of Medical SciencesStudent Research Committee, North Khorasan University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesPharmacological Research Center of Medicinal Plants, Mashhad University of Medical SciencesDepartment of Radiology, Mashhad Medical Sciences Branch, Islamic Azad UniversityDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition Sciences, Varastegan Institute for Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesAbstract Introduction Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome (MS)-related liver disorder that has an increasing prevalence. Thus, the aim of our study is to evaluate the effects of pomegranate peel extract (PP) supplementation on hepatic status and metabolic syndrome risk factors. Methods In phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. Then, in phase two, NAFLD patients received 1500 mg of placebo (n = 37) or pomegranate peel capsules (n = 39) with a 500-kcal deficit diet for 8 weeks. Gastrointestinal intolerance, dietary intake, lipid and glycemic profiles, systolic and diastolic blood pressure, body composition, insulin resistance indexes, and elastography-evaluated NAFLD changes were followed. Results The mean age of participants was 43.1 ± 8.6 years (51.3% female). Following the intervention, the mean body weight (mean changes: -5.10 ± 2.30 kg), waist circumference (-7.57 ± 2.97 cm), body mass index (-1.82 ± 0.85 kg/m2), body fat index (-1.49 ± 0.86), and trunk fat (− 3.93 ± 3.07%), systolic (-0.63 ± 0.29 cmHg) and diastolic (-0.39 ± 0.19 cmHg) blood pressure, total cholesterol (-10.51 ± 0.77 mg/dl), triglyceride (-16.02 ± 1.7 mg/dl), low-density lipoprotein cholesterol (-9.33 ± 6.66 mg/dl; all P < 0.001), fat free mass (− 0.92 ± 0.90 kg; P < 0.003), and fasting blood sugar (-5.28 ± 1.36 mg/dl; P = 0.02) decreased significantly in PP in contrast to the placebo group in the raw model and when adjusted for confounders. Also, high-density lipoprotein cholesterol (5.10 ± 0.36 mg/dl), liver steatosis and stiffness (− 0.30 ± 0.17 and − 0.72 ± 0.35 kPa, respectively, all P < 0.001) improved in the PP group. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw and even adjusted models. Conclusion In conclusion, 1500 mg pomegranate peel extract along with a weight-loss diet improved metabolic syndrome risk factors and reduced hepatic steatosis in patients with NAFLD after 8 weeks.https://doi.org/10.1186/s12937-023-00869-2Pomegranate PeelMetabolic syndromeFatty liverDyslipidemiaHypertension |
| spellingShingle | Hanieh Barghchi Narges Milkarizi Saba Belyani Andisheh Norouzian Ostad Vahid Reza Askari Farnood Rajabzadeh Ladan Goshayeshi Seyede Yegane Ghelichi Kheyrabadi Maryam Razavidarmian Zahra Dehnavi Seyyed Reza Sobhani Mohsen Nematy Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial Nutrition Journal Pomegranate Peel Metabolic syndrome Fatty liver Dyslipidemia Hypertension |
| title | Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial |
| title_full | Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial |
| title_fullStr | Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial |
| title_full_unstemmed | Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial |
| title_short | Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial |
| title_sort | pomegranate punica granatum l peel extract ameliorates metabolic syndrome risk factors in patients with non alcoholic fatty liver disease a randomized double blind clinical trial |
| topic | Pomegranate Peel Metabolic syndrome Fatty liver Dyslipidemia Hypertension |
| url | https://doi.org/10.1186/s12937-023-00869-2 |
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