Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity
Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. In this review, an overview of the pharmacology, pharmacokinetics, and toxicity of scopoletin is provided. In ad...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1268464/full |
| _version_ | 1827342583871832064 |
|---|---|
| author | Xiao-Yan Gao Xiao-Yan Gao Xiao-Yan Gao Xu-Yang Li Xu-Yang Li Cong-Ying Zhang Cong-Ying Zhang Cong-Ying Zhang Chun-Ying Bai Chun-Ying Bai |
| author_facet | Xiao-Yan Gao Xiao-Yan Gao Xiao-Yan Gao Xu-Yang Li Xu-Yang Li Cong-Ying Zhang Cong-Ying Zhang Cong-Ying Zhang Chun-Ying Bai Chun-Ying Bai |
| author_sort | Xiao-Yan Gao |
| collection | DOAJ |
| description | Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. In this review, an overview of the pharmacology, pharmacokinetics, and toxicity of scopoletin is provided. In addition, the prospects and outlook for future studies are appraised. Scopoletin is indicated to have antimicrobial, anticancer, anti-inflammation, anti-angiogenesis, anti-oxidation, antidiabetic, antihypertensive, hepatoprotective, and neuroprotective properties and immunomodulatory effects in both in vitro and in vivo experimental trials. In addition, it is an inhibitor of various enzymes, including choline acetyltransferase, acetylcholinesterase, and monoamine oxidase. Pharmacokinetic studies have demonstrated the low bioavailability, rapid absorption, and extensive metabolism of scopoletin. These properties may be associated with its poor solubility in aqueous media. In addition, toxicity research indicates the non-toxicity of scopoletin to most cell types tested to date, suggesting that scopoletin will neither induce treatment-associated mortality nor abnormal performance with the test dose. Considering its favorable pharmacological activities, scopoletin has the potential to act as a drug candidate in the treatment of cancer, liver disease, diabetes, neurodegenerative disease, and mental disorders. In view of its merits and limitations, scopoletin is a suitable lead compound for the development of new, efficient, and low-toxicity derivatives. Additional studies are needed to explore its molecular mechanisms and targets, verify its toxicity, and promote its oral bioavailability. |
| first_indexed | 2024-03-07T22:09:40Z |
| format | Article |
| id | doaj.art-f3133e612f0741ccb5d99b6702b72a35 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-07T22:09:40Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f3133e612f0741ccb5d99b6702b72a352024-02-23T17:15:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.12684641268464Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicityXiao-Yan Gao0Xiao-Yan Gao1Xiao-Yan Gao2Xu-Yang Li3Xu-Yang Li4Cong-Ying Zhang5Cong-Ying Zhang6Cong-Ying Zhang7Chun-Ying Bai8Chun-Ying Bai9Basic Medicine College, Chifeng University, Chifeng, ChinaInner Mongolia Key Laboratory of Human Genetic Disease Research, Chifeng University, Chifeng, ChinaKey Laboratory of Mechanism and Evaluation of Chinese and Mongolian Pharmacy at Chifeng University, Chifeng University, Chifeng, ChinaBasic Medicine College, Chifeng University, Chifeng, ChinaInner Mongolia Key Laboratory of Human Genetic Disease Research, Chifeng University, Chifeng, ChinaBasic Medicine College, Chifeng University, Chifeng, ChinaInner Mongolia Key Laboratory of Human Genetic Disease Research, Chifeng University, Chifeng, ChinaKey Laboratory of Mechanism and Evaluation of Chinese and Mongolian Pharmacy at Chifeng University, Chifeng University, Chifeng, ChinaBasic Medicine College, Chifeng University, Chifeng, ChinaInner Mongolia Key Laboratory of Human Genetic Disease Research, Chifeng University, Chifeng, ChinaScopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. In this review, an overview of the pharmacology, pharmacokinetics, and toxicity of scopoletin is provided. In addition, the prospects and outlook for future studies are appraised. Scopoletin is indicated to have antimicrobial, anticancer, anti-inflammation, anti-angiogenesis, anti-oxidation, antidiabetic, antihypertensive, hepatoprotective, and neuroprotective properties and immunomodulatory effects in both in vitro and in vivo experimental trials. In addition, it is an inhibitor of various enzymes, including choline acetyltransferase, acetylcholinesterase, and monoamine oxidase. Pharmacokinetic studies have demonstrated the low bioavailability, rapid absorption, and extensive metabolism of scopoletin. These properties may be associated with its poor solubility in aqueous media. In addition, toxicity research indicates the non-toxicity of scopoletin to most cell types tested to date, suggesting that scopoletin will neither induce treatment-associated mortality nor abnormal performance with the test dose. Considering its favorable pharmacological activities, scopoletin has the potential to act as a drug candidate in the treatment of cancer, liver disease, diabetes, neurodegenerative disease, and mental disorders. In view of its merits and limitations, scopoletin is a suitable lead compound for the development of new, efficient, and low-toxicity derivatives. Additional studies are needed to explore its molecular mechanisms and targets, verify its toxicity, and promote its oral bioavailability.https://www.frontiersin.org/articles/10.3389/fphar.2024.1268464/fullscopoletinplant sourcespharmacological activitiespharmacokineticstoxicology |
| spellingShingle | Xiao-Yan Gao Xiao-Yan Gao Xiao-Yan Gao Xu-Yang Li Xu-Yang Li Cong-Ying Zhang Cong-Ying Zhang Cong-Ying Zhang Chun-Ying Bai Chun-Ying Bai Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity Frontiers in Pharmacology scopoletin plant sources pharmacological activities pharmacokinetics toxicology |
| title | Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity |
| title_full | Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity |
| title_fullStr | Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity |
| title_full_unstemmed | Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity |
| title_short | Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity |
| title_sort | scopoletin a review of its pharmacology pharmacokinetics and toxicity |
| topic | scopoletin plant sources pharmacological activities pharmacokinetics toxicology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1268464/full |
| work_keys_str_mv | AT xiaoyangao scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT xiaoyangao scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT xiaoyangao scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT xuyangli scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT xuyangli scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT congyingzhang scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT congyingzhang scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT congyingzhang scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT chunyingbai scopoletinareviewofitspharmacologypharmacokineticsandtoxicity AT chunyingbai scopoletinareviewofitspharmacologypharmacokineticsandtoxicity |