Optimizing the Dutch newborn screening for congenital hypothyroidism by incorporating amino acids and acylcarnitines in a machine learning-based model

Optimizing the Dutch newborn screening for congenital hypothyroidism by incorporating amino acids and acylcarnitines in a machine learning-based model

Objective: Congenital hypothyroidism (CH) is an inborn thyroid hormone (TH) deficiency mostly caused by thyroidal (primary CH) or hypothalamic/pituitary (central CH) disturbances. Most CH newborn screening (NBS) programs are thyroid-stimulating-hormone (TSH) based, thereby only detecting primary CH....

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Bibliographic Details
Main Authors: Heleen I Jansen, Marije van Haeringen, Marelle J Bouva, Wendy P J den Elzen, Eveline Bruinstroop, Catharina P B van der Ploeg, A S Paul van Trotsenburg, Nitash Zwaveling-Soonawala, Annemieke C Heijboer, Annet M Bosch, Robert de Jonge, Mark Hoogendoorn, Anita Boelen
Format: Article
Language:English
Published: Bioscientifica 2023-11-01
Series:European Thyroid Journal
Subjects:
congenital hypothyroidism
newborn screening
amino acids
acylcarnitines
machine learning based
Online Access:https://etj.bioscientifica.com/view/journals/etj/12/6/ETJ-23-0141.xml

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https://etj.bioscientifica.com/view/journals/etj/12/6/ETJ-23-0141.xml

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