Evaluating the expression of heat shock protein 27 and topoisomerase II α in a retrospective cohort of patients diagnosed with locally advanced breast cancer and treated with neoadjuvant anthracycline-based chemotherapies

Evaluating the expression of heat shock protein 27 and topoisomerase II α in a retrospective cohort of patients diagnosed with locally advanced breast cancer and treated with neoadjuvant anthracycline-based chemotherapies

BackgroundNeoadjuvant anthracycline-based chemotherapy (NAC) is a major regimen for the treatment of local advanced breast cancer (LABC), while resistance to NAC remains a paramount clinical obstacle. To investigate the role of heat shock protein 27 (Hsp27) and/or topoisomerase IIα (TopoIIα) in LABC...

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Bibliographic Details
Main Authors: Yixuan Zhuang, Fan Zhang, Yue Xu, Lifang He, Wenhe Huang, Chaoqun Hong, Yukun Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
Hsp27
TopoIIα
locally advanced breast cancer
anthracycline
neoadjuvant chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1067179/full

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