Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship
Infectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observat...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/6/659 |
| _version_ | 1827306594442936320 |
|---|---|
| author | Adriana-Ionela Pătrașcu Dan Vâță Doinița Temelie-Olinici Mădălina Mocanu Dumitrița-Lenuța Guguluș Mădălina Marinescu Liviu Stafie Bogdan-Marian Tarcău Ioana Creţu Ioana-Adriana Popescu Carmen-Diana Cimpoeșu Laura Gheucă-Solovăstru |
| author_facet | Adriana-Ionela Pătrașcu Dan Vâță Doinița Temelie-Olinici Mădălina Mocanu Dumitrița-Lenuța Guguluș Mădălina Marinescu Liviu Stafie Bogdan-Marian Tarcău Ioana Creţu Ioana-Adriana Popescu Carmen-Diana Cimpoeșu Laura Gheucă-Solovăstru |
| author_sort | Adriana-Ionela Pătrașcu |
| collection | DOAJ |
| description | Infectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020–2022 in the largest emergency hospital in NE Romania. Of 509 patients, 441 had infected lesions, 78 had sepsis caused by venous ulcers from microbial eczema cellulitis, superinfected bullous dermatoses, erysipelas, and erythroderma. Cultured samples revealed <i>S. aureus</i>, <i>P. aeruginosa</i>, and <i>E. coli</i>; and <i>K. pneumoniae</i> and <i>S. β-hemolytic</i> associated with sepsis, even if this was rarer. Clinical manifestations included ulcerations, erosions, fissures, excoriations, bullae, vesicles, pruritus, tumefaction, edema, fever, chills, pain, adenopathy, and mildly altered mental status. Underlying chronic heart failure, atrial fibrillation, anemia, and type-1 diabetes mellitus were comorbidities associated with infection and sepsis. Significant associations and risk factors, including their combined effects, are discussed to draw attention to the need for further research and adequate management to prevent sepsis in adult patients of any age presenting with infected skin lesions (especially cellulitis) and comorbidities (especially type 1 diabetes mellitus and anemia). |
| first_indexed | 2024-04-24T18:24:05Z |
| format | Article |
| id | doaj.art-f317347175344aff9658b97259a7c5cc |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T18:24:05Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f317347175344aff9658b97259a7c5cc2024-03-27T13:33:28ZengMDPI AGDiagnostics2075-44182024-03-0114665910.3390/diagnostics14060659Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis RelationshipAdriana-Ionela Pătrașcu0Dan Vâță1Doinița Temelie-Olinici2Mădălina Mocanu3Dumitrița-Lenuța Guguluș4Mădălina Marinescu5Liviu Stafie6Bogdan-Marian Tarcău7Ioana Creţu8Ioana-Adriana Popescu9Carmen-Diana Cimpoeșu10Laura Gheucă-Solovăstru11Clinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaClinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaClinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaClinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaDiscipline of Dermatology-Venereology, Department of Medical Sciences III, Faculty of Medicine “Grigore T. Popa”, University of Medicine and Pharmacy, 700115 Iași, RomaniaDiscipline of Dermatology-Venereology, Department of Medical Sciences III, Faculty of Medicine “Grigore T. Popa”, University of Medicine and Pharmacy, 700115 Iași, RomaniaDiscipline of Public Health and Management, Department of Preventive Medicine and Interdisciplinarity, Faculty of Medicine “Grigore T. Popa”, University of Medicine and Pharmacy, 700115 Iași, RomaniaClinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaCrețu R. Ioana Persoană Fizică Autorizată, 707020 Aroneanu, RomaniaClinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaDiscipline of Emergency, Medicine Department of Surgery II, Faculty of Medicine “Grigore T. Popa”, University of Medicine and Pharmacy, 700115 Iași, RomaniaClinic of Dermatology-Venereology, “Saint Spiridon” Emergency County Clinical Hospital, 700111 Iași, RomaniaInfectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020–2022 in the largest emergency hospital in NE Romania. Of 509 patients, 441 had infected lesions, 78 had sepsis caused by venous ulcers from microbial eczema cellulitis, superinfected bullous dermatoses, erysipelas, and erythroderma. Cultured samples revealed <i>S. aureus</i>, <i>P. aeruginosa</i>, and <i>E. coli</i>; and <i>K. pneumoniae</i> and <i>S. β-hemolytic</i> associated with sepsis, even if this was rarer. Clinical manifestations included ulcerations, erosions, fissures, excoriations, bullae, vesicles, pruritus, tumefaction, edema, fever, chills, pain, adenopathy, and mildly altered mental status. Underlying chronic heart failure, atrial fibrillation, anemia, and type-1 diabetes mellitus were comorbidities associated with infection and sepsis. Significant associations and risk factors, including their combined effects, are discussed to draw attention to the need for further research and adequate management to prevent sepsis in adult patients of any age presenting with infected skin lesions (especially cellulitis) and comorbidities (especially type 1 diabetes mellitus and anemia).https://www.mdpi.com/2075-4418/14/6/659skin lesions with loss of tissuecutaneous-onset sepsisacute infectionsskin microbiome |
| spellingShingle | Adriana-Ionela Pătrașcu Dan Vâță Doinița Temelie-Olinici Mădălina Mocanu Dumitrița-Lenuța Guguluș Mădălina Marinescu Liviu Stafie Bogdan-Marian Tarcău Ioana Creţu Ioana-Adriana Popescu Carmen-Diana Cimpoeșu Laura Gheucă-Solovăstru Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship Diagnostics skin lesions with loss of tissue cutaneous-onset sepsis acute infections skin microbiome |
| title | Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship |
| title_full | Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship |
| title_fullStr | Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship |
| title_full_unstemmed | Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship |
| title_short | Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship |
| title_sort | skin lesions with loss of tissue and cutaneous onset sepsis the skin infection sepsis relationship |
| topic | skin lesions with loss of tissue cutaneous-onset sepsis acute infections skin microbiome |
| url | https://www.mdpi.com/2075-4418/14/6/659 |
| work_keys_str_mv | AT adrianaionelapatrascu skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT danvata skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT doinitatemelieolinici skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT madalinamocanu skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT dumitritalenutagugulus skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT madalinamarinescu skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT liviustafie skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT bogdanmariantarcau skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT ioanacretu skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT ioanaadrianapopescu skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT carmendianacimpoesu skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship AT lauragheucasolovastru skinlesionswithlossoftissueandcutaneousonsetsepsistheskininfectionsepsisrelationship |