CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis

CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis

Intracellular chloride channel protein 1 (CLIC1) participates in inflammatory processes by regulating macrophage phagosomal functions such as pH and proteolysis. Here, we sought to determine if CLIC1 can regulate adaptive immunity by actions on dendritic cells (DCs), the key professional antigen pre...

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Bibliographic Details
Main Authors: Kanin Salao, Lele Jiang, Hui Li, Vicky W.-W. Tsai, Yasmin Husaini, Paul M. G. Curmi, Louise J. Brown, David A. Brown, Samuel N. Breit
Format: Article
Language:English
Published: The Company of Biologists 2016-05-01
Series:Biology Open
Subjects:
CLIC1
Dendritic cells
Phagosome
Acidification
Proteolysis
Antigen presentation
Online Access:http://bio.biologists.org/content/5/5/620

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