Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review
In Indonesia, the noni plant (Morinda citrifolia L.) has gained popularity as an alternative treatment for various diseases. Cancer is the second cause of death worldwide, with chemotherapy as the primary treatment. There is growing interest in exploring phytochemicals found in noni plants such as a...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine
2023-08-01
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| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Online Access: | https://jurnal.uii.ac.id/JKKI/article/view/24620 |
| _version_ | 1797679464289665024 |
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| author | Oktavia Beni Kujariningrum Sri Winarni Kharisma Olivia Anugrah Cahyani Nadia Puji Anggitasari Waviq Azizah |
| author_facet | Oktavia Beni Kujariningrum Sri Winarni Kharisma Olivia Anugrah Cahyani Nadia Puji Anggitasari Waviq Azizah |
| author_sort | Oktavia Beni Kujariningrum |
| collection | DOAJ |
| description | In Indonesia, the noni plant (Morinda citrifolia L.) has gained popularity as an alternative treatment for various diseases. Cancer is the second cause of death worldwide, with chemotherapy as the primary treatment. There is growing interest in exploring phytochemicals found in noni plants such as anthraquinones, chitosan, phenols, and flavonoids. These antioxidant compounds hold potential as alternative treatments for cancer. This study explores the active compounds in noni plants that exhibit anti-cancer properties. This study employed a scoping review approach. Previous original articles were retrieved from Scopus, Science Direct, ClinicalKey, Springer Link, and Google Scholar with keywords in Morinda citrifolia L., component, bioactive, antioxidant, anti-inflammatory, and anti-cancer. We included 34 articles that met the inclusion criteria. The findings of this study highlight the anti-cancer activity of several phytochemicals found in noni plants. Damnacanthal has been shown to reduce the number of MCF-7 cells. Nordamnacanthal inhibited the development of the H400 cell cycle by increasing the activity of Cytochrome C, Caspase-9, and Caspase 3/7 and induced the death of MDA-MB231 and MCF-7 cells. Chitosan nanoparticles can inhibit the growth of A549 cells. Scopoletin can inhibit cancer cell proliferation by inducing cells in the G0 / G1 and S phases. Epicatechin can inhibit the growth of PC-9 cells. Damnachanthal, nordamnacanthal, chitosan nanoparticles, scopoletin, and epicatechin are active compounds presented in noni plants that can act as anti-cancer. |
| first_indexed | 2024-03-11T23:15:03Z |
| format | Article |
| id | doaj.art-f31943cd35d84ccfb04d8a5fdd14315d |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-03-11T23:15:03Z |
| publishDate | 2023-08-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-f31943cd35d84ccfb04d8a5fdd14315d2023-09-21T04:54:28ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502023-08-0118619310.20885/JKKI.Vol14.Iss2.art1034028Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping reviewOktavia Beni Kujariningrum0https://orcid.org/0000-0003-0730-0420Sri Winarni1https://orcid.org/0000-0002-9436-1581Kharisma Olivia Anugrah Cahyani2Nadia Puji Anggitasari3Waviq Azizah4Faculty of Public Health, Diponegoro University, Semarang, IndonesiaFaculty of Public Health, Diponegoro University, Semarang, IndonesiaFaculty of Public Health, Diponegoro University, Semarang, IndonesiaFaculty of Public Health, Diponegoro University, Semarang, IndonesiaFaculty of Public Health, Diponegoro University, Semarang, IndonesiaIn Indonesia, the noni plant (Morinda citrifolia L.) has gained popularity as an alternative treatment for various diseases. Cancer is the second cause of death worldwide, with chemotherapy as the primary treatment. There is growing interest in exploring phytochemicals found in noni plants such as anthraquinones, chitosan, phenols, and flavonoids. These antioxidant compounds hold potential as alternative treatments for cancer. This study explores the active compounds in noni plants that exhibit anti-cancer properties. This study employed a scoping review approach. Previous original articles were retrieved from Scopus, Science Direct, ClinicalKey, Springer Link, and Google Scholar with keywords in Morinda citrifolia L., component, bioactive, antioxidant, anti-inflammatory, and anti-cancer. We included 34 articles that met the inclusion criteria. The findings of this study highlight the anti-cancer activity of several phytochemicals found in noni plants. Damnacanthal has been shown to reduce the number of MCF-7 cells. Nordamnacanthal inhibited the development of the H400 cell cycle by increasing the activity of Cytochrome C, Caspase-9, and Caspase 3/7 and induced the death of MDA-MB231 and MCF-7 cells. Chitosan nanoparticles can inhibit the growth of A549 cells. Scopoletin can inhibit cancer cell proliferation by inducing cells in the G0 / G1 and S phases. Epicatechin can inhibit the growth of PC-9 cells. Damnachanthal, nordamnacanthal, chitosan nanoparticles, scopoletin, and epicatechin are active compounds presented in noni plants that can act as anti-cancer.https://jurnal.uii.ac.id/JKKI/article/view/24620 |
| spellingShingle | Oktavia Beni Kujariningrum Sri Winarni Kharisma Olivia Anugrah Cahyani Nadia Puji Anggitasari Waviq Azizah Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| title | Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review |
| title_full | Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review |
| title_fullStr | Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review |
| title_full_unstemmed | Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review |
| title_short | Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review |
| title_sort | bioactives of noni plant morinda citrifolia l as anti cancer herbals a scoping review |
| url | https://jurnal.uii.ac.id/JKKI/article/view/24620 |
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