Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis
Introduction: Interleukins (ILs) can act as a predictive indicator of Premature Coronary Artery Disease (pCAD) and may be useful in screening of high-risk patients. However, there is no consensus on the relationship of serum levels of ILs and pCAD, yet. As a result, this study has been conducted in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2022-06-01
|
| Series: | Archives of Academic Emergency Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1605 |
| _version_ | 1818216573527130112 |
|---|---|
| author | Mohammad Haji Aghajani Amirmohammad Toloui Koohyar Ahmadzadeh Arian Madani Neishaboori Mahmoud Yousefifard |
| author_facet | Mohammad Haji Aghajani Amirmohammad Toloui Koohyar Ahmadzadeh Arian Madani Neishaboori Mahmoud Yousefifard |
| author_sort | Mohammad Haji Aghajani |
| collection | DOAJ |
| description |
Introduction: Interleukins (ILs) can act as a predictive indicator of Premature Coronary Artery Disease (pCAD) and may be useful in screening of high-risk patients. However, there is no consensus on the relationship of serum levels of ILs and pCAD, yet. As a result, this study has been conducted in order to review the literature on the relationship between serum levels of different ILs and pCAD.
Methods: Medline, Scopus, Embase, and Web of Science databases were searched until December 7th 2020. Two reviewers independently screened and summarized eligible articles. A meta-analysis was performed to assess the relationship of ILs and pCAD.
Results: 12 case-control articles were included. IL-6 plasma changes do happen in pCAD patients with a standardized mean difference (SMD) of 0.51 (95% CI: 0.12-0.90; p=0.010) compared with the control group. This difference was also observed when evaluating the plasma levels of IL-1 and IL-17, with an SMD of 1.42 (95% CI: 1.11-1.73; p<0.001) and 0.59 (95% CI: 0.14-1.04; p=0.011), respectively. Meanwhile, no significant difference existed in plasma levels of IL-10 (SMD=0.26; 95% CI: -0.17-0.70; p=0.236), and IL-18 (SMD=1.44; 95% CI: -0.19-3.07; p=0.083) between pCAD patients and those in the control group.
Conclusion: Low level of evidence showed that there may be a significant relationship between increased plasma levels of ILs and the occurrence of pCAD. As a result, prospective cohort studies with serial assessments of serum ILs during follow up period, focusing on controlling classical risk factors of pCAD and increase in level of ILs, should be conducted.
|
| first_indexed | 2024-12-12T06:54:07Z |
| format | Article |
| id | doaj.art-f3196951f6ae4bd8af1b1f3f08cf3aaf |
| institution | Directory Open Access Journal |
| issn | 2645-4904 |
| language | English |
| last_indexed | 2024-12-12T06:54:07Z |
| publishDate | 2022-06-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj.art-f3196951f6ae4bd8af1b1f3f08cf3aaf2022-12-22T00:34:00ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042022-06-0110110.22037/aaem.v10i1.1605Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis Mohammad Haji Aghajani0Amirmohammad Toloui1Koohyar Ahmadzadeh2Arian Madani Neishaboori3Mahmoud Yousefifard41- Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2- Department of Cardiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Physiology Research Center, Iran University of Medical Sciences, Tehran, IranPhysiology Research Center, Iran University of Medical Sciences, Tehran, IranPhysiology Research Center, Iran University of Medical Sciences, Tehran, IranPhysiology Research Center, Iran University of Medical Sciences, Tehran, Iran | Email: yousefifard.m@iums.ac.ir Introduction: Interleukins (ILs) can act as a predictive indicator of Premature Coronary Artery Disease (pCAD) and may be useful in screening of high-risk patients. However, there is no consensus on the relationship of serum levels of ILs and pCAD, yet. As a result, this study has been conducted in order to review the literature on the relationship between serum levels of different ILs and pCAD. Methods: Medline, Scopus, Embase, and Web of Science databases were searched until December 7th 2020. Two reviewers independently screened and summarized eligible articles. A meta-analysis was performed to assess the relationship of ILs and pCAD. Results: 12 case-control articles were included. IL-6 plasma changes do happen in pCAD patients with a standardized mean difference (SMD) of 0.51 (95% CI: 0.12-0.90; p=0.010) compared with the control group. This difference was also observed when evaluating the plasma levels of IL-1 and IL-17, with an SMD of 1.42 (95% CI: 1.11-1.73; p<0.001) and 0.59 (95% CI: 0.14-1.04; p=0.011), respectively. Meanwhile, no significant difference existed in plasma levels of IL-10 (SMD=0.26; 95% CI: -0.17-0.70; p=0.236), and IL-18 (SMD=1.44; 95% CI: -0.19-3.07; p=0.083) between pCAD patients and those in the control group. Conclusion: Low level of evidence showed that there may be a significant relationship between increased plasma levels of ILs and the occurrence of pCAD. As a result, prospective cohort studies with serial assessments of serum ILs during follow up period, focusing on controlling classical risk factors of pCAD and increase in level of ILs, should be conducted. https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1605Coronary artery diseasecardiovascular diseaseinterleukinsPrognosisBiomarkers |
| spellingShingle | Mohammad Haji Aghajani Amirmohammad Toloui Koohyar Ahmadzadeh Arian Madani Neishaboori Mahmoud Yousefifard Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis Archives of Academic Emergency Medicine Coronary artery disease cardiovascular disease interleukins Prognosis Biomarkers |
| title | Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis |
| title_full | Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis |
| title_fullStr | Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis |
| title_full_unstemmed | Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis |
| title_short | Premature Coronary Artery Disease and Plasma Levels of Interleukins; a Systematic Scoping Review and Meta-Analysis |
| title_sort | premature coronary artery disease and plasma levels of interleukins a systematic scoping review and meta analysis |
| topic | Coronary artery disease cardiovascular disease interleukins Prognosis Biomarkers |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/1605 |
| work_keys_str_mv | AT mohammadhajiaghajani prematurecoronaryarterydiseaseandplasmalevelsofinterleukinsasystematicscopingreviewandmetaanalysis AT amirmohammadtoloui prematurecoronaryarterydiseaseandplasmalevelsofinterleukinsasystematicscopingreviewandmetaanalysis AT koohyarahmadzadeh prematurecoronaryarterydiseaseandplasmalevelsofinterleukinsasystematicscopingreviewandmetaanalysis AT arianmadanineishaboori prematurecoronaryarterydiseaseandplasmalevelsofinterleukinsasystematicscopingreviewandmetaanalysis AT mahmoudyousefifard prematurecoronaryarterydiseaseandplasmalevelsofinterleukinsasystematicscopingreviewandmetaanalysis |