Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action
Curcumin, one of the major ingredients of turmeric (<i>Curcuma longa</i>), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflamm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/4/609 |
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| author | Siti Nur Hidayah Jamil Amatul Hamizah Ali Shevin Rizal Feroz Su Datt Lam Hani Kartini Agustar Mohd Ridzuan Mohd Abd Razak Jalifah Latip |
| author_facet | Siti Nur Hidayah Jamil Amatul Hamizah Ali Shevin Rizal Feroz Su Datt Lam Hani Kartini Agustar Mohd Ridzuan Mohd Abd Razak Jalifah Latip |
| author_sort | Siti Nur Hidayah Jamil |
| collection | DOAJ |
| description | Curcumin, one of the major ingredients of turmeric (<i>Curcuma longa</i>), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure–activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation. |
| first_indexed | 2024-03-11T04:38:50Z |
| format | Article |
| id | doaj.art-f31d89621b0049f58f7f36e841bca6bd |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T04:38:50Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f31d89621b0049f58f7f36e841bca6bd2023-11-17T20:51:21ZengMDPI AGPharmaceuticals1424-82472023-04-0116460910.3390/ph16040609Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of ActionSiti Nur Hidayah Jamil0Amatul Hamizah Ali1Shevin Rizal Feroz2Su Datt Lam3Hani Kartini Agustar4Mohd Ridzuan Mohd Abd Razak5Jalifah Latip6Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaDepartment of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaDepartment of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaDepartment of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaDepartment of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaHerbal Medicine Research Centre, Institute for Medical Research, National Institute of Health (NIH) Complex, Ministry of Health Malaysia, Shah Alam 40170, Selangor, MalaysiaDepartment of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, MalaysiaCurcumin, one of the major ingredients of turmeric (<i>Curcuma longa</i>), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin’s low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure–activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation.https://www.mdpi.com/1424-8247/16/4/609curcumin derivativesantimalariaanti-inflammatorystructure–activity relationshipmolecular targets |
| spellingShingle | Siti Nur Hidayah Jamil Amatul Hamizah Ali Shevin Rizal Feroz Su Datt Lam Hani Kartini Agustar Mohd Ridzuan Mohd Abd Razak Jalifah Latip Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action Pharmaceuticals curcumin derivatives antimalaria anti-inflammatory structure–activity relationship molecular targets |
| title | Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action |
| title_full | Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action |
| title_fullStr | Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action |
| title_full_unstemmed | Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action |
| title_short | Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure–Activity Relationship and Mechanism of Action |
| title_sort | curcumin and its derivatives as potential antimalarial and anti inflammatory agents a review on structure activity relationship and mechanism of action |
| topic | curcumin derivatives antimalaria anti-inflammatory structure–activity relationship molecular targets |
| url | https://www.mdpi.com/1424-8247/16/4/609 |
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