NAD+-Metabolizing Ectoenzymes in Remodeling Tumor–Host Interactions: The Human Myeloma Model

NAD+-Metabolizing Ectoenzymes in Remodeling Tumor–Host Interactions: The Human Myeloma Model

Nicotinamide adenine dinucleotide (NAD+) is an essential co-enzyme reported to operate both intra- and extracellularly. In the extracellular space, NAD+ can elicit signals by binding purinergic P2 receptors or it can serve as the substrate for a chain of ectoenzymes. As a substrate, it is converted...

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Bibliographic Details
Main Authors: Alberto L. Horenstein, Antonella Chillemi, Valeria Quarona, Andrea Zito, Ilaria Roato, Fabio Morandi, Danilo Marimpietri, Marina Bolzoni, Denise Toscani, Robert J. Oldham, Massimiliano Cuccioloni, A. Kate Sasser, Vito Pistoia, Nicola Giuliani, Fabio Malavasi
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Cells
Subjects:
NAD+
CD38
ectoenzymes
adenosine
multiple myeloma
Daratumumab
Online Access:http://www.mdpi.com/2073-4409/4/3/520

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