Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis
Chronic liver injury induces the activation of hepatic stellate cells (HSCs) into myofibroblasts, which produce excessive amounts of extracellular matrix (ECM), resulting in tissue fibrosis. If the injury persists, these fibrous scars could be permanent and disrupt liver architecture and function. C...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/3/378 |
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| author | Archittapon Nokkeaw Pannathon Thamjamrassri Pisit Tangkijvanich Chaiyaboot Ariyachet |
| author_facet | Archittapon Nokkeaw Pannathon Thamjamrassri Pisit Tangkijvanich Chaiyaboot Ariyachet |
| author_sort | Archittapon Nokkeaw |
| collection | DOAJ |
| description | Chronic liver injury induces the activation of hepatic stellate cells (HSCs) into myofibroblasts, which produce excessive amounts of extracellular matrix (ECM), resulting in tissue fibrosis. If the injury persists, these fibrous scars could be permanent and disrupt liver architecture and function. Currently, effective anti-fibrotic therapies are lacking; hence, understanding molecular mechanisms that control HSC activation could hold a key to the development of new treatments. Recently, emerging studies have revealed roles of circular RNAs (circRNAs), a class of non-coding RNAs that was initially assumed to be the result of splicing errors, as new regulators in HSC activation. These circRNAs can modulate the activity of microRNAs (miRNAs) and their interacting protein partners involved in regulating fibrogenic signaling cascades. In this review, we will summarize the current knowledge of this class of non-coding RNAs for their molecular function in HSC activation and liver fibrosis progression. |
| first_indexed | 2024-03-11T09:49:38Z |
| format | Article |
| id | doaj.art-f3202998bbe94c3b9cf83a33f1ed4a2a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:49:38Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f3202998bbe94c3b9cf83a33f1ed4a2a2023-11-16T16:20:46ZengMDPI AGCells2073-44092023-01-0112337810.3390/cells12030378Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver FibrosisArchittapon Nokkeaw0Pannathon Thamjamrassri1Pisit Tangkijvanich2Chaiyaboot Ariyachet3Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandChronic liver injury induces the activation of hepatic stellate cells (HSCs) into myofibroblasts, which produce excessive amounts of extracellular matrix (ECM), resulting in tissue fibrosis. If the injury persists, these fibrous scars could be permanent and disrupt liver architecture and function. Currently, effective anti-fibrotic therapies are lacking; hence, understanding molecular mechanisms that control HSC activation could hold a key to the development of new treatments. Recently, emerging studies have revealed roles of circular RNAs (circRNAs), a class of non-coding RNAs that was initially assumed to be the result of splicing errors, as new regulators in HSC activation. These circRNAs can modulate the activity of microRNAs (miRNAs) and their interacting protein partners involved in regulating fibrogenic signaling cascades. In this review, we will summarize the current knowledge of this class of non-coding RNAs for their molecular function in HSC activation and liver fibrosis progression.https://www.mdpi.com/2073-4409/12/3/378non-coding RNAcircular RNAmicroRNAhepatic stellate cellsliver fibrosis |
| spellingShingle | Archittapon Nokkeaw Pannathon Thamjamrassri Pisit Tangkijvanich Chaiyaboot Ariyachet Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis Cells non-coding RNA circular RNA microRNA hepatic stellate cells liver fibrosis |
| title | Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis |
| title_full | Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis |
| title_fullStr | Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis |
| title_full_unstemmed | Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis |
| title_short | Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis |
| title_sort | regulatory functions and mechanisms of circular rnas in hepatic stellate cell activation and liver fibrosis |
| topic | non-coding RNA circular RNA microRNA hepatic stellate cells liver fibrosis |
| url | https://www.mdpi.com/2073-4409/12/3/378 |
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