Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits
The A-kinase anchoring protein 12 gene (<i>AKAP12</i>) is a scaffold protein, which can target multiple signal transduction effectors, can promote mitosis and cytokinesis and plays an important role in the regulation of growth and development. In our previous study, P1–7 bp (intron 3) an...
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MDPI AG
2021-07-01
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| author | Yangyang Bai Rongrong Yuan Yunyun Luo Zihong Kang Haijing Zhu Lei Qu Xianyong Lan Xiaoyue Song |
| author_facet | Yangyang Bai Rongrong Yuan Yunyun Luo Zihong Kang Haijing Zhu Lei Qu Xianyong Lan Xiaoyue Song |
| author_sort | Yangyang Bai |
| collection | DOAJ |
| description | The A-kinase anchoring protein 12 gene (<i>AKAP12</i>) is a scaffold protein, which can target multiple signal transduction effectors, can promote mitosis and cytokinesis and plays an important role in the regulation of growth and development. In our previous study, P1–7 bp (intron 3) and P2–13 bp (3′UTR) indels within the <i>AKAP12</i> gene significantly influenced <i>AKAP12</i> gene expression. Therefore, this study aimed to identify the association between these two genetic variations and growth-related traits in Shaanbei white cashmere goats (SBWC) (n = 1405). Herein, we identified two non-linkage insertions/deletions (indels). Notably, we found that the P1–7 bp indel mutation was related to the height at hip cross (HHC; <i>p</i> < 0.05) and the P2–13 bp indel was associated with body weight, body length, chest depth, chest width, hip width, chest circumference and cannon (bone) circumference in SBWC goats (<i>p</i> < 0.05). Overall, the two indels’ mutations of <i>AKAP12</i> affected growth traits in goats. Compared to the P1–7 bp indel, the P2–13 bp indel is more suitable for the breeding of goat growth traits. |
| first_indexed | 2024-03-10T09:48:26Z |
| format | Article |
| id | doaj.art-f32161be937e408bb71b7aec71831845 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T09:48:26Z |
| publishDate | 2021-07-01 |
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| record_format | Article |
| series | Animals |
| spelling | doaj.art-f32161be937e408bb71b7aec718318452023-11-22T03:02:14ZengMDPI AGAnimals2076-26152021-07-01117209010.3390/ani11072090Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth TraitsYangyang Bai0Rongrong Yuan1Yunyun Luo2Zihong Kang3Haijing Zhu4Lei Qu5Xianyong Lan6Xiaoyue Song7Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, ChinaShaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaShaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, ChinaShaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaShaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, ChinaThe A-kinase anchoring protein 12 gene (<i>AKAP12</i>) is a scaffold protein, which can target multiple signal transduction effectors, can promote mitosis and cytokinesis and plays an important role in the regulation of growth and development. In our previous study, P1–7 bp (intron 3) and P2–13 bp (3′UTR) indels within the <i>AKAP12</i> gene significantly influenced <i>AKAP12</i> gene expression. Therefore, this study aimed to identify the association between these two genetic variations and growth-related traits in Shaanbei white cashmere goats (SBWC) (n = 1405). Herein, we identified two non-linkage insertions/deletions (indels). Notably, we found that the P1–7 bp indel mutation was related to the height at hip cross (HHC; <i>p</i> < 0.05) and the P2–13 bp indel was associated with body weight, body length, chest depth, chest width, hip width, chest circumference and cannon (bone) circumference in SBWC goats (<i>p</i> < 0.05). Overall, the two indels’ mutations of <i>AKAP12</i> affected growth traits in goats. Compared to the P1–7 bp indel, the P2–13 bp indel is more suitable for the breeding of goat growth traits.https://www.mdpi.com/2076-2615/11/7/2090goatA-kinase anchoring protein 12 (<i>AKAP12</i>)insertion/deletion (indel)growth traits |
| spellingShingle | Yangyang Bai Rongrong Yuan Yunyun Luo Zihong Kang Haijing Zhu Lei Qu Xianyong Lan Xiaoyue Song Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits Animals goat A-kinase anchoring protein 12 (<i>AKAP12</i>) insertion/deletion (indel) growth traits |
| title | Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits |
| title_full | Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits |
| title_fullStr | Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits |
| title_full_unstemmed | Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits |
| title_short | Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (<i>AKAP12</i>) Gene and Their Effects on Growth Traits |
| title_sort | exploration of genetic variants within the goat a kinase anchoring protein 12 i akap12 i gene and their effects on growth traits |
| topic | goat A-kinase anchoring protein 12 (<i>AKAP12</i>) insertion/deletion (indel) growth traits |
| url | https://www.mdpi.com/2076-2615/11/7/2090 |
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