Exosomes and development of cancer cell resistance to metformin: pilot study
Objective: to study the role of the intercellular interactions in the progression of the cancer cells resistance to metformin, a biguanide antidiabetic drug exhibited the marked anti-tumor activity.Results. Earlier we have demonstrated the effect of horizontal transferring of hormonal resistance of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-10-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/106 |
| _version_ | 1797696868597104640 |
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| author | S. E. Semina E. A. Rudenskaya A. G. Mittenberg S. V. Shabel’nikov M. A. Krasil’nikov |
| author_facet | S. E. Semina E. A. Rudenskaya A. G. Mittenberg S. V. Shabel’nikov M. A. Krasil’nikov |
| author_sort | S. E. Semina |
| collection | DOAJ |
| description | Objective: to study the role of the intercellular interactions in the progression of the cancer cells resistance to metformin, a biguanide antidiabetic drug exhibited the marked anti-tumor activity.Results. Earlier we have demonstrated the effect of horizontal transferring of hormonal resistance of breast cancer cells from cell to cell, and showed the key role of exosomes on the transferring of the resistance. Here we have shown the effect of the horizontal transferring of metformin resistance in breast cancer cells – similar to the progression of hormonal resistance. We found that horizontal transferring of the metformin resistance is mediated via exosomes secreted by the resistant cells. The proteome analysis of the exosomes revealed several proteins differentially expressed in the exosomes of metformin-resistant cells and associated with the regulation of cell response to apoptotic drugs.Conclusions. Totally, the data presented demonstrate the new mechanism of the development of the cancer cell resistance based on the intercellular interactions, opening the new insights in the target therapy of breast cancer. |
| first_indexed | 2024-03-12T03:32:21Z |
| format | Article |
| id | doaj.art-f32216435e5742caa95463a7f125429a |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2024-03-12T03:32:21Z |
| publishDate | 2017-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-f32216435e5742caa95463a7f125429a2023-09-03T13:24:39ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872017-10-0143929810.17650/2313-805X-2017-4-3-92-98101Exosomes and development of cancer cell resistance to metformin: pilot studyS. E. Semina0E. A. Rudenskaya1A. G. Mittenberg2S. V. Shabel’nikov3M. A. Krasil’nikov4НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.ФГБУН «Институт цитологии Российской академии наук».ФГБУН «Институт цитологии Российской академии наук».НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.Objective: to study the role of the intercellular interactions in the progression of the cancer cells resistance to metformin, a biguanide antidiabetic drug exhibited the marked anti-tumor activity.Results. Earlier we have demonstrated the effect of horizontal transferring of hormonal resistance of breast cancer cells from cell to cell, and showed the key role of exosomes on the transferring of the resistance. Here we have shown the effect of the horizontal transferring of metformin resistance in breast cancer cells – similar to the progression of hormonal resistance. We found that horizontal transferring of the metformin resistance is mediated via exosomes secreted by the resistant cells. The proteome analysis of the exosomes revealed several proteins differentially expressed in the exosomes of metformin-resistant cells and associated with the regulation of cell response to apoptotic drugs.Conclusions. Totally, the data presented demonstrate the new mechanism of the development of the cancer cell resistance based on the intercellular interactions, opening the new insights in the target therapy of breast cancer.https://umo.abvpress.ru/jour/article/view/106рак молочной железырезистентностьметформинэкзосомымежклеточное взаимодействиепротеом |
| spellingShingle | S. E. Semina E. A. Rudenskaya A. G. Mittenberg S. V. Shabel’nikov M. A. Krasil’nikov Exosomes and development of cancer cell resistance to metformin: pilot study Успехи молекулярной онкологии рак молочной железы резистентность метформин экзосомы межклеточное взаимодействие протеом |
| title | Exosomes and development of cancer cell resistance to metformin: pilot study |
| title_full | Exosomes and development of cancer cell resistance to metformin: pilot study |
| title_fullStr | Exosomes and development of cancer cell resistance to metformin: pilot study |
| title_full_unstemmed | Exosomes and development of cancer cell resistance to metformin: pilot study |
| title_short | Exosomes and development of cancer cell resistance to metformin: pilot study |
| title_sort | exosomes and development of cancer cell resistance to metformin pilot study |
| topic | рак молочной железы резистентность метформин экзосомы межклеточное взаимодействие протеом |
| url | https://umo.abvpress.ru/jour/article/view/106 |
| work_keys_str_mv | AT sesemina exosomesanddevelopmentofcancercellresistancetometforminpilotstudy AT earudenskaya exosomesanddevelopmentofcancercellresistancetometforminpilotstudy AT agmittenberg exosomesanddevelopmentofcancercellresistancetometforminpilotstudy AT svshabelnikov exosomesanddevelopmentofcancercellresistancetometforminpilotstudy AT makrasilnikov exosomesanddevelopmentofcancercellresistancetometforminpilotstudy |