Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial.
<h4>Introduction</h4>Varenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated varenicline tartrate plus Qui...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0231095 |
| _version_ | 1818369093854560256 |
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| author | Kristin V Carson-Chahhoud Brian J Smith Matthew J Peters Malcolm P Brinn Faisal Ameer Kuljit Singh Robert Fitridge Simon A Koblar Jim Jannes Antony J Veale Sharon Goldsworthy Khin Hnin Adrian J Esterman |
| author_facet | Kristin V Carson-Chahhoud Brian J Smith Matthew J Peters Malcolm P Brinn Faisal Ameer Kuljit Singh Robert Fitridge Simon A Koblar Jim Jannes Antony J Veale Sharon Goldsworthy Khin Hnin Adrian J Esterman |
| author_sort | Kristin V Carson-Chahhoud |
| collection | DOAJ |
| description | <h4>Introduction</h4>Varenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated varenicline tartrate plus Quitline-counselling compared to Quitline-counselling alone.<h4>Methods</h4>Adult patients (n = 392, 20-75 years) admitted with a smoking-related illnesses to one of three hospitals, were randomised to receive either 12-weeks of varenicline tartrate (titrated from 0.5mg daily to 1mg twice-daily) plus Quitline-counselling, (n = 196) or Quitline-counselling alone, (n = 196), with continuous abstinence from smoking assessed at 104 weeks.<h4>Results</h4>A total of 1959 potential participants were screened for eligibility between August 2008 and December 2011. The proportion of participants who remained continuously abstinent (intention-to-treat) at 104 weeks were significantly greater in the varenicline tartrate plus counselling arm (29.2% n = 56) compared to counselling alone (18.8% n = 36; p = 0.02; odds ratio 1.78; 95%CI 1.10 to 2.86, p = 0.02). Twenty-two deaths occurred during the 104 week study (n = 10 for varenicline tartrate plus counselling and n = 12 for Quitline-counselling alone). All of these participants had known or developed underlying co-morbidities.<h4>Conclusions</h4>This is the first study to examine the efficacy and safety of varenicline tartrate over 104 weeks within any setting. Varenicline tartrate plus Quitline-counselling was found to be an effective opportunistic treatment when initiated for inpatient smokers who had been admitted with tobacco-related disease. |
| first_indexed | 2024-12-13T23:18:22Z |
| format | Article |
| id | doaj.art-f322c3afba7d4a90891e341a53c923b0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T23:18:22Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-f322c3afba7d4a90891e341a53c923b02022-12-21T23:27:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023109510.1371/journal.pone.0231095Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial.Kristin V Carson-ChahhoudBrian J SmithMatthew J PetersMalcolm P BrinnFaisal AmeerKuljit SinghRobert FitridgeSimon A KoblarJim JannesAntony J VealeSharon GoldsworthyKhin HninAdrian J Esterman<h4>Introduction</h4>Varenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated varenicline tartrate plus Quitline-counselling compared to Quitline-counselling alone.<h4>Methods</h4>Adult patients (n = 392, 20-75 years) admitted with a smoking-related illnesses to one of three hospitals, were randomised to receive either 12-weeks of varenicline tartrate (titrated from 0.5mg daily to 1mg twice-daily) plus Quitline-counselling, (n = 196) or Quitline-counselling alone, (n = 196), with continuous abstinence from smoking assessed at 104 weeks.<h4>Results</h4>A total of 1959 potential participants were screened for eligibility between August 2008 and December 2011. The proportion of participants who remained continuously abstinent (intention-to-treat) at 104 weeks were significantly greater in the varenicline tartrate plus counselling arm (29.2% n = 56) compared to counselling alone (18.8% n = 36; p = 0.02; odds ratio 1.78; 95%CI 1.10 to 2.86, p = 0.02). Twenty-two deaths occurred during the 104 week study (n = 10 for varenicline tartrate plus counselling and n = 12 for Quitline-counselling alone). All of these participants had known or developed underlying co-morbidities.<h4>Conclusions</h4>This is the first study to examine the efficacy and safety of varenicline tartrate over 104 weeks within any setting. Varenicline tartrate plus Quitline-counselling was found to be an effective opportunistic treatment when initiated for inpatient smokers who had been admitted with tobacco-related disease.https://doi.org/10.1371/journal.pone.0231095 |
| spellingShingle | Kristin V Carson-Chahhoud Brian J Smith Matthew J Peters Malcolm P Brinn Faisal Ameer Kuljit Singh Robert Fitridge Simon A Koblar Jim Jannes Antony J Veale Sharon Goldsworthy Khin Hnin Adrian J Esterman Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial. PLoS ONE |
| title | Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial. |
| title_full | Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial. |
| title_fullStr | Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial. |
| title_full_unstemmed | Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial. |
| title_short | Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial. |
| title_sort | two year efficacy of varenicline tartrate and counselling for inpatient smoking cessation stop study a randomized controlled clinical trial |
| url | https://doi.org/10.1371/journal.pone.0231095 |
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