Kimyrsa and Orbactiv – A Tale of Two Formulations

Brittany T Jackson,1 David B Cluck,2 Andrés F Henao-Martínez,3 Daniel B Chastain4 1Department of Pharmacy, Mount Sinai Morningside, New York, NY, 10025, USA; 2Department of Pharmacy Practice, Bill Gatton College of Pharmacy East Tennessee State University, Johnson City, TN, 37614, USA; 3Division of...

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Bibliographic Details
Main Authors: Jackson BT, Cluck DB, Henao-Martínez AF, Chastain DB
Format: Article
Language:English
Published: Dove Medical Press 2023-03-01
Series:Drug Design, Development and Therapy
Subjects:
Online Access:https://www.dovepress.com/kimyrsa-and-orbactiv--a-tale-of-two-formulations-peer-reviewed-fulltext-article-DDDT
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Summary:Brittany T Jackson,1 David B Cluck,2 Andrés F Henao-Martínez,3 Daniel B Chastain4 1Department of Pharmacy, Mount Sinai Morningside, New York, NY, 10025, USA; 2Department of Pharmacy Practice, Bill Gatton College of Pharmacy East Tennessee State University, Johnson City, TN, 37614, USA; 3Division of Infectious Diseases, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA; 4Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Albany, GA, 31701, USACorrespondence: Brittany T Jackson, Department of Pharmacy, Mount Sinai Morningside, New York, NY, 10025, USA, Email brittany.jackson@mountsinai.orgAbstract: Kimyrsa is a new formulation (NF) of the original formulation of oritavancin ([OF] Orbactiv). Comparatively, the obvious benefit with this product is the shortened infusion time and flexibility with solution compatibility, but otherwise maintains a similar pharmacokinetic and microbiologic profile. At present, the NF lacks significant real-world experience relative to other available lipoglycopeptides and thus its place in therapy remains difficult to predict but would not be expected to be significantly different than its OF.Keywords: Kimyrsa, Orbactiv, oritavancin, glycopeptides, ABSSSI, soft tissue infections, pharmacokinetics
ISSN:1177-8881