Portable Waveguide-Based Optical Biosensor
Rapid, on-site diagnostics allow for timely intervention and response for warfighter support, environmental monitoring, and global health needs. Portable optical biosensors are being widely pursued as a means of achieving fieldable biosensing due to the potential speed and accuracy of optical detect...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/4/195 |
| _version_ | 1827621598949015552 |
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| author | Philip A. Kocheril Kiersten D. Lenz David D. L. Mascareñas John E. Morales-Garcia Aaron S. Anderson Harshini Mukundan |
| author_facet | Philip A. Kocheril Kiersten D. Lenz David D. L. Mascareñas John E. Morales-Garcia Aaron S. Anderson Harshini Mukundan |
| author_sort | Philip A. Kocheril |
| collection | DOAJ |
| description | Rapid, on-site diagnostics allow for timely intervention and response for warfighter support, environmental monitoring, and global health needs. Portable optical biosensors are being widely pursued as a means of achieving fieldable biosensing due to the potential speed and accuracy of optical detection. We recently developed the portable engineered analytic sensor with automated sampling (PEGASUS) with the goal of developing a fieldable, generalizable biosensing platform. Here, we detail the development of PEGASUS’s sensing hardware and use a test-bed system of identical sensing hardware and software to demonstrate detection of a fluorescent conjugate at 1 nM through biotin-streptavidin chemistry. |
| first_indexed | 2024-03-09T11:06:39Z |
| format | Article |
| id | doaj.art-f3243272b6204636a075e5c4de841a3e |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T11:06:39Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-f3243272b6204636a075e5c4de841a3e2023-12-01T00:57:40ZengMDPI AGBiosensors2079-63742022-03-0112419510.3390/bios12040195Portable Waveguide-Based Optical BiosensorPhilip A. Kocheril0Kiersten D. Lenz1David D. L. Mascareñas2John E. Morales-Garcia3Aaron S. Anderson4Harshini Mukundan5Physical Chemistry and Applied Spectroscopy Group, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USAPhysical Chemistry and Applied Spectroscopy Group, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USANational Security Education Center, Los Alamos National Laboratory, Los Alamos, NM 87545, USANational Security Education Center, Los Alamos National Laboratory, Los Alamos, NM 87545, USAPhysical Chemistry and Applied Spectroscopy Group, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USAPhysical Chemistry and Applied Spectroscopy Group, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USARapid, on-site diagnostics allow for timely intervention and response for warfighter support, environmental monitoring, and global health needs. Portable optical biosensors are being widely pursued as a means of achieving fieldable biosensing due to the potential speed and accuracy of optical detection. We recently developed the portable engineered analytic sensor with automated sampling (PEGASUS) with the goal of developing a fieldable, generalizable biosensing platform. Here, we detail the development of PEGASUS’s sensing hardware and use a test-bed system of identical sensing hardware and software to demonstrate detection of a fluorescent conjugate at 1 nM through biotin-streptavidin chemistry.https://www.mdpi.com/2079-6374/12/4/195biosensorportablefluorescencewaveguideevanescent field |
| spellingShingle | Philip A. Kocheril Kiersten D. Lenz David D. L. Mascareñas John E. Morales-Garcia Aaron S. Anderson Harshini Mukundan Portable Waveguide-Based Optical Biosensor Biosensors biosensor portable fluorescence waveguide evanescent field |
| title | Portable Waveguide-Based Optical Biosensor |
| title_full | Portable Waveguide-Based Optical Biosensor |
| title_fullStr | Portable Waveguide-Based Optical Biosensor |
| title_full_unstemmed | Portable Waveguide-Based Optical Biosensor |
| title_short | Portable Waveguide-Based Optical Biosensor |
| title_sort | portable waveguide based optical biosensor |
| topic | biosensor portable fluorescence waveguide evanescent field |
| url | https://www.mdpi.com/2079-6374/12/4/195 |
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