High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection
Here, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al. investigate viral dynamics in fatal cases of COVID-19, revealing persistent infection in distinct anatomical sites, including the heart and testis.
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34256-y |
| _version_ | 1811171671619403776 |
|---|---|
| author | Erica Normandin Melissa Rudy Nikolaos Barkas Stephen F. Schaffner Zoe Levine Robert F. Padera Mehrtash Babadi Shibani S. Mukerji Daniel J. Park Bronwyn L. MacInnis Katherine J. Siddle Pardis C. Sabeti Isaac H. Solomon |
| author_facet | Erica Normandin Melissa Rudy Nikolaos Barkas Stephen F. Schaffner Zoe Levine Robert F. Padera Mehrtash Babadi Shibani S. Mukerji Daniel J. Park Bronwyn L. MacInnis Katherine J. Siddle Pardis C. Sabeti Isaac H. Solomon |
| author_sort | Erica Normandin |
| collection | DOAJ |
| description | Here, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al. investigate viral dynamics in fatal cases of COVID-19, revealing persistent infection in distinct anatomical sites, including the heart and testis. |
| first_indexed | 2024-04-10T17:17:50Z |
| format | Article |
| id | doaj.art-f3271dabc2c74b9d8e1372480f2f4b46 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T17:17:50Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f3271dabc2c74b9d8e1372480f2f4b462023-02-05T12:18:31ZengNature PortfolioNature Communications2041-17232023-02-0114111210.1038/s41467-022-34256-yHigh-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infectionErica Normandin0Melissa Rudy1Nikolaos Barkas2Stephen F. Schaffner3Zoe Levine4Robert F. Padera5Mehrtash Babadi6Shibani S. Mukerji7Daniel J. Park8Bronwyn L. MacInnis9Katherine J. Siddle10Pardis C. Sabeti11Isaac H. Solomon12Broad Institute of Harvard and MITBroad Institute of Harvard and MITBroad Institute of Harvard and MITBroad Institute of Harvard and MITBroad Institute of Harvard and MITDepartment of Pathology, Brigham and Women’s HospitalBroad Institute of Harvard and MITDepartment of Neurology, Massachusetts General HospitalBroad Institute of Harvard and MITBroad Institute of Harvard and MITBroad Institute of Harvard and MITBroad Institute of Harvard and MITDepartment of Pathology, Brigham and Women’s HospitalHere, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al. investigate viral dynamics in fatal cases of COVID-19, revealing persistent infection in distinct anatomical sites, including the heart and testis.https://doi.org/10.1038/s41467-022-34256-y |
| spellingShingle | Erica Normandin Melissa Rudy Nikolaos Barkas Stephen F. Schaffner Zoe Levine Robert F. Padera Mehrtash Babadi Shibani S. Mukerji Daniel J. Park Bronwyn L. MacInnis Katherine J. Siddle Pardis C. Sabeti Isaac H. Solomon High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection Nature Communications |
| title | High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection |
| title_full | High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection |
| title_fullStr | High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection |
| title_full_unstemmed | High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection |
| title_short | High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection |
| title_sort | high depth sequencing characterization of viral dynamics across tissues in fatal covid 19 reveals compartmentalized infection |
| url | https://doi.org/10.1038/s41467-022-34256-y |
| work_keys_str_mv | AT ericanormandin highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT melissarudy highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT nikolaosbarkas highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT stephenfschaffner highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT zoelevine highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT robertfpadera highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT mehrtashbabadi highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT shibanismukerji highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT danieljpark highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT bronwynlmacinnis highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT katherinejsiddle highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT pardiscsabeti highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection AT isaachsolomon highdepthsequencingcharacterizationofviraldynamicsacrosstissuesinfatalcovid19revealscompartmentalizedinfection |