Efficacy of ozone therapy on visual evoked potentials in diabetic patients
Abstract Background The involvement of the central nervous system is a frequent yet underestimated complication of diabetes mellitus. Visual evoked potentials (VEP) are a simple, sensitive, and noninvasive method for detecting early alterations in central optic pathways. The objective of this parall...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01114-w |
| _version_ | 1797784527725133824 |
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| author | Morteza Izadi Mohammad Javanbakht Ali Sarafzadeh Behzad Einollahi Farzaneh Futuhi Zahra Vahedi Shi Zhao Nematollah Jonaidi-Jafari Mahboobeh Sadat Hosseini Javad Hosseini Nejad Effat Naeimi Seyed Hassan Saadat Hadi Esmaeili Gouvarchin Ghaleh Mozhgan Fazel Zahra Einollahi Luca Cegolon |
| author_facet | Morteza Izadi Mohammad Javanbakht Ali Sarafzadeh Behzad Einollahi Farzaneh Futuhi Zahra Vahedi Shi Zhao Nematollah Jonaidi-Jafari Mahboobeh Sadat Hosseini Javad Hosseini Nejad Effat Naeimi Seyed Hassan Saadat Hadi Esmaeili Gouvarchin Ghaleh Mozhgan Fazel Zahra Einollahi Luca Cegolon |
| author_sort | Morteza Izadi |
| collection | DOAJ |
| description | Abstract Background The involvement of the central nervous system is a frequent yet underestimated complication of diabetes mellitus. Visual evoked potentials (VEP) are a simple, sensitive, and noninvasive method for detecting early alterations in central optic pathways. The objective of this paralleled randomized controlled trial was to evaluate the impact of ozone therapy on visual pathways in diabetic patients. Methods Sixty patients with type 2 diabetes visiting clinics of Baqiyatallah university in Tehran (Iran) hospital were randomly assigned to two experimental groups: Group 1 (N = 30) undergoing a cycle of 20 sessions of systemic oxygen-ozone therapy in addition to standard therapy for metabolic control; Group 2 (N = 30)—serving as control—receiving only standard therapy against diabetes. The primary study endpoints were two VEP parameters; P100 wave latency and P100 amplitude at 3 months. Moreover, HbA1c levels were measured before the start of treatment and three months later as secondary study endpoint. Results All 60 patients completed the clinical trial. P100 latency significantly reduced at 3 months since baseline. No correlation was found between repeated measures of P100 wave latency and HbA1c (Pearson’s r = 0.169, p = 0.291). There was no significant difference between baseline values and repeated measures of P100 wave amplitude over time in either group. No adverse effects were recorded. Conclusions Ozone therapy improved the conduction of impulses in optic pathways of diabetic patients. The improved glycemic control following ozone therpay may not fully explain the reduction of P100 wave latency though; other mechanistic effects of ozone may be involved. |
| first_indexed | 2024-03-13T00:41:11Z |
| format | Article |
| id | doaj.art-f3289b419c044ed881e4a8cff46a591a |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-03-13T00:41:11Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-f3289b419c044ed881e4a8cff46a591a2023-07-09T11:20:03ZengBMCDiabetology & Metabolic Syndrome1758-59962023-06-0115111010.1186/s13098-023-01114-wEfficacy of ozone therapy on visual evoked potentials in diabetic patientsMorteza Izadi0Mohammad Javanbakht1Ali Sarafzadeh2Behzad Einollahi3Farzaneh Futuhi4Zahra Vahedi5Shi Zhao6Nematollah Jonaidi-Jafari7Mahboobeh Sadat Hosseini8Javad Hosseini Nejad9Effat Naeimi10Seyed Hassan Saadat11Hadi Esmaeili Gouvarchin Ghaleh12Mozhgan Fazel13Zahra Einollahi14Luca Cegolon15Health Research Center, Baqiyatallah University of Medical SciencesNephrology and Urology Research Center, Clinical Science Institute, Baqiyatallah University of Medical SciencesDepartment of Biostatistics, Faculty of Medicine, Guilan University of Medical SciencesNephrology and Urology Research Center, Clinical Science Institute, Baqiyatallah University of Medical SciencesNephrology Department, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesDepartment of Pediatrics, School of Medicine, Hazrat-E Ali. Asghar Pediatrics Hospital, Iran University of Medical SciencesJC School of Public Health and Primary Care, Chinese University of Hong KongHealth Research Center, Baqiyatallah University of Medical SciencesHealth Research Center, Lifestyle Institute, Baqiyatallah University of Medical SciencesNeuroscience Research Center, Baqiyatallah University of Medical SciencesEndocrinology and Metabolism Department, Baqiyatallah University of Medical SciencesBehavioral Sciences Research Center, Lifestyle Institute, Baqiyatallah University of Medical SciencesApplied Virology Research Center, Baqiyatallah University of Medical SciencesOzone CRC, BMSUNephrology Research Center, Shariati Hospital, Tehran University of Medical SciencesDepartment of Medical, Surgical & Health Sciences, University of TriesteAbstract Background The involvement of the central nervous system is a frequent yet underestimated complication of diabetes mellitus. Visual evoked potentials (VEP) are a simple, sensitive, and noninvasive method for detecting early alterations in central optic pathways. The objective of this paralleled randomized controlled trial was to evaluate the impact of ozone therapy on visual pathways in diabetic patients. Methods Sixty patients with type 2 diabetes visiting clinics of Baqiyatallah university in Tehran (Iran) hospital were randomly assigned to two experimental groups: Group 1 (N = 30) undergoing a cycle of 20 sessions of systemic oxygen-ozone therapy in addition to standard therapy for metabolic control; Group 2 (N = 30)—serving as control—receiving only standard therapy against diabetes. The primary study endpoints were two VEP parameters; P100 wave latency and P100 amplitude at 3 months. Moreover, HbA1c levels were measured before the start of treatment and three months later as secondary study endpoint. Results All 60 patients completed the clinical trial. P100 latency significantly reduced at 3 months since baseline. No correlation was found between repeated measures of P100 wave latency and HbA1c (Pearson’s r = 0.169, p = 0.291). There was no significant difference between baseline values and repeated measures of P100 wave amplitude over time in either group. No adverse effects were recorded. Conclusions Ozone therapy improved the conduction of impulses in optic pathways of diabetic patients. The improved glycemic control following ozone therpay may not fully explain the reduction of P100 wave latency though; other mechanistic effects of ozone may be involved.https://doi.org/10.1186/s13098-023-01114-wDiabetes mellitusHbA1cOzone therapyVisual evoked potentials |
| spellingShingle | Morteza Izadi Mohammad Javanbakht Ali Sarafzadeh Behzad Einollahi Farzaneh Futuhi Zahra Vahedi Shi Zhao Nematollah Jonaidi-Jafari Mahboobeh Sadat Hosseini Javad Hosseini Nejad Effat Naeimi Seyed Hassan Saadat Hadi Esmaeili Gouvarchin Ghaleh Mozhgan Fazel Zahra Einollahi Luca Cegolon Efficacy of ozone therapy on visual evoked potentials in diabetic patients Diabetology & Metabolic Syndrome Diabetes mellitus HbA1c Ozone therapy Visual evoked potentials |
| title | Efficacy of ozone therapy on visual evoked potentials in diabetic patients |
| title_full | Efficacy of ozone therapy on visual evoked potentials in diabetic patients |
| title_fullStr | Efficacy of ozone therapy on visual evoked potentials in diabetic patients |
| title_full_unstemmed | Efficacy of ozone therapy on visual evoked potentials in diabetic patients |
| title_short | Efficacy of ozone therapy on visual evoked potentials in diabetic patients |
| title_sort | efficacy of ozone therapy on visual evoked potentials in diabetic patients |
| topic | Diabetes mellitus HbA1c Ozone therapy Visual evoked potentials |
| url | https://doi.org/10.1186/s13098-023-01114-w |
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