Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components
Temporal and spatial tumor heterogeneity can be observed in pancreatic neuroendocrine tumor. We report the case of a young woman with long term stabilization of a G2 metastatic pancreatic NET that, after pregnancy, suddenly progressed into one single liver metastasis corresponding to a transformatio...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.646992/full |
| _version_ | 1818413378679341056 |
|---|---|
| author | Jean-Luc Raoul Marie-Françoise Heymann Frédéric Dumont Alain Morel Hélène Senellart François Bertucci |
| author_facet | Jean-Luc Raoul Marie-Françoise Heymann Frédéric Dumont Alain Morel Hélène Senellart François Bertucci |
| author_sort | Jean-Luc Raoul |
| collection | DOAJ |
| description | Temporal and spatial tumor heterogeneity can be observed in pancreatic neuroendocrine tumor. We report the case of a young woman with long term stabilization of a G2 metastatic pancreatic NET that, after pregnancy, suddenly progressed into one single liver metastasis corresponding to a transformation into G3 large-cell neuroendocrine cancer. The patient underwent liver resection (the progressive and one dormant metastasis). With a 45 months follow-up the patient is without evolutive disease. Exome sequencing of the two metastases revealed completely different genomic signatures and gene alterations: the dormant metastasis was MSS without any gene alteration; the poorly differentiated tumor was MSI, with gain of many mutations including MEN1, BCL2, MLH1 and TP53 corresponding to a mutational signature 11. Could temozolomide play a role in this transformation? |
| first_indexed | 2024-12-14T11:02:15Z |
| format | Article |
| id | doaj.art-f32967a550a04c258f9a15d374733eaa |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T11:02:15Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f32967a550a04c258f9a15d374733eaa2022-12-21T23:04:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.646992646992Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two ComponentsJean-Luc Raoul0Marie-Françoise Heymann1Frédéric Dumont2Alain Morel3Hélène Senellart4François Bertucci5Department of Medical Oncology, Institut de Cancérologie de l’Ouest, Saint-Herblain, FranceDepartment of Pathology, Institut de Cancérologie de l’Ouest, Saint-Herblain, FranceDepartment of Surgery, Institut de Cancérologie de l’Ouest, Saint-Herblain, FranceDepartment of Oncopharmacology, Institut de Cancérologie de l’Ouest, Angers, FranceDepartment of Medical Oncology, Institut de Cancérologie de l’Ouest, Saint-Herblain, FrancePredictive Oncology Laboratory, Department of Medical Oncology, CRCM, Institut Paoli-Calmettes, Aix-Marseille Université, Marseille, FranceTemporal and spatial tumor heterogeneity can be observed in pancreatic neuroendocrine tumor. We report the case of a young woman with long term stabilization of a G2 metastatic pancreatic NET that, after pregnancy, suddenly progressed into one single liver metastasis corresponding to a transformation into G3 large-cell neuroendocrine cancer. The patient underwent liver resection (the progressive and one dormant metastasis). With a 45 months follow-up the patient is without evolutive disease. Exome sequencing of the two metastases revealed completely different genomic signatures and gene alterations: the dormant metastasis was MSS without any gene alteration; the poorly differentiated tumor was MSI, with gain of many mutations including MEN1, BCL2, MLH1 and TP53 corresponding to a mutational signature 11. Could temozolomide play a role in this transformation?https://www.frontiersin.org/articles/10.3389/fonc.2021.646992/fullsporadic gastrinomametastasessurgerygenomicsMEN 1 genemicrosatellite instability |
| spellingShingle | Jean-Luc Raoul Marie-Françoise Heymann Frédéric Dumont Alain Morel Hélène Senellart François Bertucci Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components Frontiers in Oncology sporadic gastrinoma metastases surgery genomics MEN 1 gene microsatellite instability |
| title | Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components |
| title_full | Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components |
| title_fullStr | Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components |
| title_full_unstemmed | Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components |
| title_short | Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components |
| title_sort | case report grade 2 metastatic pancreatic neuroendocrine tumor with progression of one metastasis after pregnancy to grade 3 large cell neuroendocrine carcinoma one case cured by resection with genomic characterization of the two components |
| topic | sporadic gastrinoma metastases surgery genomics MEN 1 gene microsatellite instability |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.646992/full |
| work_keys_str_mv | AT jeanlucraoul casereportgrade2metastaticpancreaticneuroendocrinetumorwithprogressionofonemetastasisafterpregnancytograde3largecellneuroendocrinecarcinomaonecasecuredbyresectionwithgenomiccharacterizationofthetwocomponents AT mariefrancoiseheymann casereportgrade2metastaticpancreaticneuroendocrinetumorwithprogressionofonemetastasisafterpregnancytograde3largecellneuroendocrinecarcinomaonecasecuredbyresectionwithgenomiccharacterizationofthetwocomponents AT fredericdumont casereportgrade2metastaticpancreaticneuroendocrinetumorwithprogressionofonemetastasisafterpregnancytograde3largecellneuroendocrinecarcinomaonecasecuredbyresectionwithgenomiccharacterizationofthetwocomponents AT alainmorel casereportgrade2metastaticpancreaticneuroendocrinetumorwithprogressionofonemetastasisafterpregnancytograde3largecellneuroendocrinecarcinomaonecasecuredbyresectionwithgenomiccharacterizationofthetwocomponents AT helenesenellart casereportgrade2metastaticpancreaticneuroendocrinetumorwithprogressionofonemetastasisafterpregnancytograde3largecellneuroendocrinecarcinomaonecasecuredbyresectionwithgenomiccharacterizationofthetwocomponents AT francoisbertucci casereportgrade2metastaticpancreaticneuroendocrinetumorwithprogressionofonemetastasisafterpregnancytograde3largecellneuroendocrinecarcinomaonecasecuredbyresectionwithgenomiccharacterizationofthetwocomponents |