Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients.
Citrullinated proteins have been discovered in the joints of patients with rheumatoid arthritis but not in other forms of joint disease. The citrullinated proteins in the joints correspond to the presence of the citrulline antibodies in the blood and suggest a possible role for these antibodies in t...
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| Format: | Article |
| Language: | English |
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University of Anbar
2013-08-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
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| Online Access: | https://juaps.uoanbar.edu.iq/article_78249_0c7a00c8f84dbf37035ed25c3d2d381c.pdf |
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| author | Hanaa N. Abdullah Amina N.Al-Thuwani Mohamed I. Nadi Khudhair Al-Badri |
| author_facet | Hanaa N. Abdullah Amina N.Al-Thuwani Mohamed I. Nadi Khudhair Al-Badri |
| author_sort | Hanaa N. Abdullah |
| collection | DOAJ |
| description | Citrullinated proteins have been discovered in the joints of patients with rheumatoid arthritis but not in other forms of joint disease. The citrullinated proteins in the joints correspond to the presence of the citrulline antibodies in the blood and suggest a possible role for these antibodies in the development of rheumatoid arthritis. The present study assessed the recent diagnostic value of anti-cyclic citrullinated antibodies (CCP) compared with rheumatoid factor (RF) in patients with rheumatoid arthritis. One hundred blood samples were collected from RA patients and thirty from apparently healthy group. Sera from each subject were tested for anti- CCP and RF by enzyme linked immunosorbent assay (ELISA). The majority of patients were females (84%), with a female: male ratio 5.2:1. The results indicated that anti-CCP postivity for RA patients was (69%) when compared with the healthy group (0.0%), which was highly significant in RA in comparison with control groups (P<0.001). The current study revealed that the sensitivity and specificity of Anti-CCP appeared the highest (69%) in comparison with low (47%) sensitivity for RF. Moreover, the specificity of Anti-CCP was very high (100%), while the specificity of RF was high (90%). |
| first_indexed | 2024-03-08T18:48:34Z |
| format | Article |
| id | doaj.art-f329b11dd05b49d5b09fdd22f4d25c6d |
| institution | Directory Open Access Journal |
| issn | 1991-8941 2706-6703 |
| language | English |
| last_indexed | 2024-03-08T18:48:34Z |
| publishDate | 2013-08-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | مجلة جامعة الانبار للعلوم الصرفة |
| spelling | doaj.art-f329b11dd05b49d5b09fdd22f4d25c6d2023-12-28T21:56:20ZengUniversity of Anbarمجلة جامعة الانبار للعلوم الصرفة1991-89412706-67032013-08-01631610.37652/juaps.2012.7824978249Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients.Hanaa N. Abdullah0Amina N.Al-Thuwani1Mohamed I. Nadi2Khudhair Al-Badri3Foundation of technical education - College of Health and medical technologyUniversity of Baghdad- Institute Genetics Engineering and biotechnology for Postgraduate .University of Baghdad- Institute Genetics Engineering and biotechnology for Postgraduate .University of Baghdad - College of Medicine.Citrullinated proteins have been discovered in the joints of patients with rheumatoid arthritis but not in other forms of joint disease. The citrullinated proteins in the joints correspond to the presence of the citrulline antibodies in the blood and suggest a possible role for these antibodies in the development of rheumatoid arthritis. The present study assessed the recent diagnostic value of anti-cyclic citrullinated antibodies (CCP) compared with rheumatoid factor (RF) in patients with rheumatoid arthritis. One hundred blood samples were collected from RA patients and thirty from apparently healthy group. Sera from each subject were tested for anti- CCP and RF by enzyme linked immunosorbent assay (ELISA). The majority of patients were females (84%), with a female: male ratio 5.2:1. The results indicated that anti-CCP postivity for RA patients was (69%) when compared with the healthy group (0.0%), which was highly significant in RA in comparison with control groups (P<0.001). The current study revealed that the sensitivity and specificity of Anti-CCP appeared the highest (69%) in comparison with low (47%) sensitivity for RF. Moreover, the specificity of Anti-CCP was very high (100%), while the specificity of RF was high (90%).https://juaps.uoanbar.edu.iq/article_78249_0c7a00c8f84dbf37035ed25c3d2d381c.pdfdiagnostic valueanticcp antibodiesrheumatoid |
| spellingShingle | Hanaa N. Abdullah Amina N.Al-Thuwani Mohamed I. Nadi Khudhair Al-Badri Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. مجلة جامعة الانبار للعلوم الصرفة diagnostic value anti ccp antibodies rheumatoid |
| title | Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. |
| title_full | Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. |
| title_fullStr | Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. |
| title_full_unstemmed | Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. |
| title_short | Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. |
| title_sort | diagnostic value of anti ccp antibodies compared with rheumatoid factor in rheumatoid arthritis patients |
| topic | diagnostic value anti ccp antibodies rheumatoid |
| url | https://juaps.uoanbar.edu.iq/article_78249_0c7a00c8f84dbf37035ed25c3d2d381c.pdf |
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